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D228 is an orally active antiinflammatory agent. D228 reduces ConA induced T lymphocyte cell proliferation (IC50: 42.85 μM) and LPS induced B lymphocyte cell proliferation (IC50: 3.15 μM). D228 is effective against inflammatory bowel disease (IBD). D228 alleviates the DSS (HY-116282C)-induced inflammation response in the IBD model by downregulating the MyD88/TRAF6/p38 signaling.

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D228 Chemical Structure

D228 Chemical Structure

CAS No. : 2676188-98-8

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Based on 1 publication(s) in Google Scholar

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Description

D228 is an orally active antiinflammatory agent. D228 reduces ConA induced T lymphocyte cell proliferation (IC50: 42.85 μM) and LPS induced B lymphocyte cell proliferation (IC50: 3.15 μM). D228 is effective against inflammatory bowel disease (IBD). D228 alleviates the DSS (HY-116282C)-induced inflammation response in the IBD model by downregulating the MyD88/TRAF6/p38 signaling[1].

Molecular Weight

484.45

Formula

C22H28O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C(/C(O1)=C(C)\C)=O)O[C@H]2[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0642 mL 10.3210 mL 20.6420 mL
5 mM 0.4128 mL 2.0642 mL 4.1284 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0642 mL 10.3210 mL 20.6420 mL 51.6049 mL
5 mM 0.4128 mL 2.0642 mL 4.1284 mL 10.3210 mL
10 mM 0.2064 mL 1.0321 mL 2.0642 mL 5.1605 mL
15 mM 0.1376 mL 0.6881 mL 1.3761 mL 3.4403 mL
20 mM 0.1032 mL 0.5160 mL 1.0321 mL 2.5802 mL
25 mM 0.0826 mL 0.4128 mL 0.8257 mL 2.0642 mL
30 mM 0.0688 mL 0.3440 mL 0.6881 mL 1.7202 mL
40 mM 0.0516 mL 0.2580 mL 0.5160 mL 1.2901 mL
50 mM 0.0413 mL 0.2064 mL 0.4128 mL 1.0321 mL
60 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8601 mL
80 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6451 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5160 mL
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D228 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D2282676188-98-8D 228D-228OthersIBDInhibitorinhibitorinhibit

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