2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. DACA

DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells.

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DACA Chemical Structure

DACA Chemical Structure

CAS No. : 89459-25-6

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5 mg USD 70 In-stock
10 mg USD 110 In-stock
25 mg USD 220 In-stock
50 mg USD 340 In-stock
100 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

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Topoisomerase Topo I Topo II

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Description

DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

Molecular Weight

293.36

Formula

C18H19N3O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CC2=CC3=CC=CC=C3N=C12)NCCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (340.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4088 mL 17.0439 mL 34.0878 mL
5 mM 0.6818 mL 3.4088 mL 6.8176 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4088 mL 17.0439 mL 34.0878 mL 85.2195 mL
5 mM 0.6818 mL 3.4088 mL 6.8176 mL 17.0439 mL
10 mM 0.3409 mL 1.7044 mL 3.4088 mL 8.5220 mL
15 mM 0.2273 mL 1.1363 mL 2.2725 mL 5.6813 mL
20 mM 0.1704 mL 0.8522 mL 1.7044 mL 4.2610 mL
25 mM 0.1364 mL 0.6818 mL 1.3635 mL 3.4088 mL
30 mM 0.1136 mL 0.5681 mL 1.1363 mL 2.8407 mL
40 mM 0.0852 mL 0.4261 mL 0.8522 mL 2.1305 mL
50 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7044 mL
60 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4203 mL
80 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
100 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
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DACA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DACA89459-25-6Topoisomerasehuman leukaemia CCRF-CEM cellsDNA topoisomerase I and II cleavable complexesInhibitorinhibitorinhibit

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