2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. DHODH-IN-23

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.

For research use only. We do not sell to patients.

DHODH-IN-23 Chemical Structure

DHODH-IN-23 Chemical Structure

CAS No. : 1346705-53-0

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Based on 1 publication(s) in Google Scholar

DHODH-IN-23 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer[1].

In Vitro

DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation[1].
DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-23 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U937, HL-60, THP-1, KG-1 and MV411
Concentration:
Incubation Time: 72 h
Result: Inhibited cell growth with GI50s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively.

RT-PCR[1]

Cell Line: THP-1 cells
Concentration: 72 h
Incubation Time: 0.1, 1 and 3 μM
Result: Induced CDllb mRNA expression.
In Vivo

DHODH-IN-23 (Compound A; 30 mg/kg; oral; twice daily for 21 days) shows antitumor activity in MV411 mouse xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MV411 mouse xenograft model[1]
Dosage: 30 mg/kg
Administration: Oral administration, twice daily for 21 days
Result: Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine (HY-13605) at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.
Molecular Weight

441.88

Formula

C24H21ClFNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C(NC2=C(C=C(C3=CC=CC(OCCCC)=C3)C=C2Cl)F)=O)C=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (282.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2631 mL 11.3153 mL 22.6306 mL
5 mM 0.4526 mL 2.2631 mL 4.5261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2631 mL 11.3153 mL 22.6306 mL 56.5764 mL
5 mM 0.4526 mL 2.2631 mL 4.5261 mL 11.3153 mL
10 mM 0.2263 mL 1.1315 mL 2.2631 mL 5.6576 mL
15 mM 0.1509 mL 0.7544 mL 1.5087 mL 3.7718 mL
20 mM 0.1132 mL 0.5658 mL 1.1315 mL 2.8288 mL
25 mM 0.0905 mL 0.4526 mL 0.9052 mL 2.2631 mL
30 mM 0.0754 mL 0.3772 mL 0.7544 mL 1.8859 mL
40 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4144 mL
50 mM 0.0453 mL 0.2263 mL 0.4526 mL 1.1315 mL
60 mM 0.0377 mL 0.1886 mL 0.3772 mL 0.9429 mL
80 mM 0.0283 mL 0.1414 mL 0.2829 mL 0.7072 mL
100 mM 0.0226 mL 0.1132 mL 0.2263 mL 0.5658 mL
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DHODH-IN-23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-231346705-53-0Dihydroorotate DehydrogenaseDHODHacute myeloid leukemiaAMLTHP-1MV411U937HL-60KG-1Inhibitorinhibitorinhibit

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