2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Dicloromezotiaz

Dicloromezotiaz is a potent insecticide acting on nicotinic acetylcholine receptors (nAChRs). Dicloromezotiaz can be used to control a broad range of lepidoptera.

For research use only. We do not sell to patients.

Dicloromezotiaz Chemical Structure

Dicloromezotiaz Chemical Structure

CAS No. : 1263629-39-5

Size Price Stock Quantity
5 mg USD 360 In-stock
10 mg USD 590 In-stock
25 mg USD 1180 In-stock
50 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

Dicloromezotiaz Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Dicloromezotiaz is a potent insecticide acting on nicotinic acetylcholine receptors (nAChRs). Dicloromezotiaz can be used to control a broad range of lepidoptera[1].

In Vitro

Dicloromezotiaz is a antagonist of insect nAChR channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dicloromezotiaz Related Antibodies
Molecular Weight

452.74

Formula

C19H12Cl3N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1[C-](C2=CC(Cl)=CC(Cl)=C2)C([N+](CC3=CN=C(Cl)S3)=C4C(C)=CC=CN14)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.88 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2088 mL 11.0439 mL 22.0877 mL
5 mM 0.4418 mL 2.2088 mL 4.4175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (5.52 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2088 mL 11.0439 mL 22.0877 mL 55.2193 mL
5 mM 0.4418 mL 2.2088 mL 4.4175 mL 11.0439 mL
10 mM 0.2209 mL 1.1044 mL 2.2088 mL 5.5219 mL
15 mM 0.1473 mL 0.7363 mL 1.4725 mL 3.6813 mL
20 mM 0.1104 mL 0.5522 mL 1.1044 mL 2.7610 mL
25 mM 0.0884 mL 0.4418 mL 0.8835 mL 2.2088 mL
30 mM 0.0736 mL 0.3681 mL 0.7363 mL 1.8406 mL
40 mM 0.0552 mL 0.2761 mL 0.5522 mL 1.3805 mL
50 mM 0.0442 mL 0.2209 mL 0.4418 mL 1.1044 mL
60 mM 0.0368 mL 0.1841 mL 0.3681 mL 0.9203 mL
80 mM 0.0276 mL 0.1380 mL 0.2761 mL 0.6902 mL
100 mM 0.0221 mL 0.1104 mL 0.2209 mL 0.5522 mL
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Dicloromezotiaz Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicloromezotiaz1263629-39-5nAChRNicotinic acetylcholine receptorslepidopteran pest controlinsecticideInhibitorinhibitorinhibit

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