2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. DIOA

DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist.

For research use only. We do not sell to patients.

DIOA Chemical Structure

DIOA Chemical Structure

CAS No. : 81166-47-4

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Description

DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist[1].

Molecular Weight

399.31

Formula

C20H24Cl2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC2=C(C([C@](C3CCCC3)(CCCC)C2)=O)C(Cl)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (250.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5043 mL 12.5216 mL 25.0432 mL
5 mM 0.5009 mL 2.5043 mL 5.0086 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.1%

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5043 mL 12.5216 mL 25.0432 mL 62.6080 mL
5 mM 0.5009 mL 2.5043 mL 5.0086 mL 12.5216 mL
10 mM 0.2504 mL 1.2522 mL 2.5043 mL 6.2608 mL
15 mM 0.1670 mL 0.8348 mL 1.6695 mL 4.1739 mL
20 mM 0.1252 mL 0.6261 mL 1.2522 mL 3.1304 mL
25 mM 0.1002 mL 0.5009 mL 1.0017 mL 2.5043 mL
30 mM 0.0835 mL 0.4174 mL 0.8348 mL 2.0869 mL
40 mM 0.0626 mL 0.3130 mL 0.6261 mL 1.5652 mL
50 mM 0.0501 mL 0.2504 mL 0.5009 mL 1.2522 mL
60 mM 0.0417 mL 0.2087 mL 0.4174 mL 1.0435 mL
80 mM 0.0313 mL 0.1565 mL 0.3130 mL 0.7826 mL
100 mM 0.0250 mL 0.1252 mL 0.2504 mL 0.6261 mL
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DIOA Related Classifications

Keywords:

DIOA81166-47-4Chloride ChannelCl− ChannelsInhibitorinhibitorinhibit

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