Diphenhydramine-d₅ hydrochloride

Name: Diphenhydramine-d 5 hydrochloride
Brand: MedChemExpress
SKU: HY-B0303AS1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0303AS1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Diphenhydramine-d₅ (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].

For research use only. We do not sell to patients.

Diphenhydramine-d<sub>5</sub> hydrochloride Chemical Structure

Diphenhydramine-d₅ hydrochloride Chemical Structure

CAS No. : 1219795-16-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Diphenhydramine-d₅ hydrochloride:

Diphenhydramine hydrochloride In-stock

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View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₁ Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.85

Formula

C₁₇H₁₇D₅ClNO

CAS No.

1219795-16-0

Unlabeled CAS

147-24-0

Appearance

Solid

Color

White to off-white

SMILES

CN(C)CCOC(C1=CC=CC=C1)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (336.87 mM; Need ultrasonic)

DMSO : 100 mg/mL (336.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3687 mL	16.8435 mL	33.6870 mL
5 mM	0.6737 mL	3.3687 mL	6.7374 mL
10 mM	0.3369 mL	1.6844 mL	3.3687 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.3687 mL	16.8435 mL	33.6870 mL	84.2176 mL
	5 mM	0.6737 mL	3.3687 mL	6.7374 mL	16.8435 mL
	10 mM	0.3369 mL	1.6844 mL	3.3687 mL	8.4218 mL
	15 mM	0.2246 mL	1.1229 mL	2.2458 mL	5.6145 mL
	20 mM	0.1684 mL	0.8422 mL	1.6844 mL	4.2109 mL
	25 mM	0.1347 mL	0.6737 mL	1.3475 mL	3.3687 mL
	30 mM	0.1123 mL	0.5615 mL	1.1229 mL	2.8073 mL
	40 mM	0.0842 mL	0.4211 mL	0.8422 mL	2.1054 mL
	50 mM	0.0674 mL	0.3369 mL	0.6737 mL	1.6844 mL
	60 mM	0.0561 mL	0.2807 mL	0.5615 mL	1.4036 mL
	80 mM	0.0421 mL	0.2105 mL	0.4211 mL	1.0527 mL
	100 mM	0.0337 mL	0.1684 mL	0.3369 mL	0.8422 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.