Dithiodipropionic acid

Name: Dithiodipropionic acid
Brand: MedChemExpress
SKU: HY-W014395
Rating: 4.5 (1 reviews)

Cat. No.: HY-W014395 Purity: ≥99.0%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells.

For research use only. We do not sell to patients.

Dithiodipropionic acid Chemical Structure

CAS No. : 1119-62-6

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC₅₀ value of 4.3 μM, and has weak cytotoxicity against normal L02 cells^[1].
CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1^[1].
CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.26

Formula

C₆H₁₀O₄S₂

CAS No.

1119-62-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCSSCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (475.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7560 mL	23.7801 mL	47.5602 mL
5 mM	0.9512 mL	4.7560 mL	9.5120 mL
10 mM	0.4756 mL	2.3780 mL	4.7560 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)

References

[1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7560 mL	23.7801 mL	47.5602 mL	118.9004 mL
	5 mM	0.9512 mL	4.7560 mL	9.5120 mL	23.7801 mL
	10 mM	0.4756 mL	2.3780 mL	4.7560 mL	11.8900 mL
	15 mM	0.3171 mL	1.5853 mL	3.1707 mL	7.9267 mL
	20 mM	0.2378 mL	1.1890 mL	2.3780 mL	5.9450 mL
	25 mM	0.1902 mL	0.9512 mL	1.9024 mL	4.7560 mL
	30 mM	0.1585 mL	0.7927 mL	1.5853 mL	3.9633 mL
	40 mM	0.1189 mL	0.5945 mL	1.1890 mL	2.9725 mL
	50 mM	0.0951 mL	0.4756 mL	0.9512 mL	2.3780 mL
	60 mM	0.0793 mL	0.3963 mL	0.7927 mL	1.9817 mL
	80 mM	0.0595 mL	0.2973 mL	0.5945 mL	1.4863 mL
	100 mM	0.0476 mL	0.2378 mL	0.4756 mL	1.1890 mL