DL-erythro-Dihydrosphingosine

Cat. No.: HY-101195 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2).

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DL-erythro-Dihydrosphingosine Chemical Structure

CAS No. : 3102-56-5

Size	Price	Stock	Quantity
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All PKC Isoform Specific Products:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Phospholipase A PLD Phospholipase C

Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2)^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
FL5.12	IC₅₀	3.5 μM Compound: 7	Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis	[PMID: 27475534]
HBL-100	GI₅₀	25 μM Compound: 10d	Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
HeLa	GI₅₀	15 μM Compound: 10d	Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
Jurkat	IC₅₀	3.53 μM Compound: Dihydrosphingosine	Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	3.68 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	4.9 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	6.31 μM Compound: Dihydrosphingosine	Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
SW1573	GI₅₀	4.5 μM Compound: 10d	Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
T47D	GI₅₀	22 μM Compound: 10d	Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
WiDr	GI₅₀	19 μM Compound: 10d	Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay	[PMID: 25899335]

Molecular Weight

301.52

Formula

C₁₈H₃₉NO₂

CAS No.

3102-56-5

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCC[C@H](O)[C@H](N)CO.[Relative stereochemistry.]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (99.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3165 mL	16.5826 mL	33.1653 mL
5 mM	0.6633 mL	3.3165 mL	6.6331 mL
10 mM	0.3317 mL	1.6583 mL	3.3165 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (239 KB)

Handling Instructions (2659 KB)

References

[1]. R Chao, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267(33):23459-62. [Content Brief]

[2]. Hiroyuki Nakamura, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3165 mL	16.5826 mL	33.1653 mL	82.9132 mL
	5 mM	0.6633 mL	3.3165 mL	6.6331 mL	16.5826 mL
	10 mM	0.3317 mL	1.6583 mL	3.3165 mL	8.2913 mL
	15 mM	0.2211 mL	1.1055 mL	2.2110 mL	5.5275 mL
	20 mM	0.1658 mL	0.8291 mL	1.6583 mL	4.1457 mL
	25 mM	0.1327 mL	0.6633 mL	1.3266 mL	3.3165 mL
	30 mM	0.1106 mL	0.5528 mL	1.1055 mL	2.7638 mL
	40 mM	0.0829 mL	0.4146 mL	0.8291 mL	2.0728 mL
	50 mM	0.0663 mL	0.3317 mL	0.6633 mL	1.6583 mL
	60 mM	0.0553 mL	0.2764 mL	0.5528 mL	1.3819 mL
	80 mM	0.0415 mL	0.2073 mL	0.4146 mL	1.0364 mL