DL-Norepinephrine-d₆ hydrochloride

Name: DL-Norepinephrine-d 6 hydrochloride
Brand: MedChemExpress
SKU: HY-N7142S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N7142S Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-Norepinephrine-d₆ (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[1].

For research use only. We do not sell to patients.

DL-Norepinephrine-d<sub>6</sub> hydrochloride Chemical Structure

DL-Norepinephrine-d₆ hydrochloride Chemical Structure

CAS No. : 1219803-04-9

Size	Price	Stock	Quantity
1 mg	USD 183	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Norepinephrine-d₆ hydrochloride:

DL-Norepinephrine hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

211.68

Formula

C₈H₆D₆ClNO₃

CAS No.

1219803-04-9

Unlabeled CAS

55-27-6

Appearance

Solid

Color

White to off-white

SMILES

NC([2H])([2H])C(C1=C([2H])C(O)=C(C([2H])=C1[2H])O)([2H])O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

1M HCl : 100 mg/mL (472.41 mM; ultrasonic and adjust pH to 1 with HCl)

1 M HCL : 100 mg/mL (472.41 mM; ultrasonic and adjust pH to 1 with HCl)

DMSO : 50 mg/mL (236.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7241 mL	23.6206 mL	47.2411 mL
5 mM	0.9448 mL	4.7241 mL	9.4482 mL
10 mM	0.4724 mL	2.3621 mL	4.7241 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (254 KB) HNMR (859 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Matsuda H, et al. Effects of nitroglycerin, adenosine, noradrenaline, and isoproterenol on the myocardial oxygen tension. Jpn Heart J. 1979 Nov;20(6):867-79. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / 1M HCl / 1 M HCL	1 mM	4.7241 mL	23.6206 mL	47.2411 mL	118.1028 mL
	5 mM	0.9448 mL	4.7241 mL	9.4482 mL	23.6206 mL
	10 mM	0.4724 mL	2.3621 mL	4.7241 mL	11.8103 mL
	15 mM	0.3149 mL	1.5747 mL	3.1494 mL	7.8735 mL
	20 mM	0.2362 mL	1.1810 mL	2.3621 mL	5.9051 mL
	25 mM	0.1890 mL	0.9448 mL	1.8896 mL	4.7241 mL
	30 mM	0.1575 mL	0.7874 mL	1.5747 mL	3.9368 mL
	40 mM	0.1181 mL	0.5905 mL	1.1810 mL	2.9526 mL
	50 mM	0.0945 mL	0.4724 mL	0.9448 mL	2.3621 mL
	60 mM	0.0787 mL	0.3937 mL	0.7874 mL	1.9684 mL
	80 mM	0.0591 mL	0.2953 mL	0.5905 mL	1.4763 mL
	100 mM	0.0472 mL	0.2362 mL	0.4724 mL	1.1810 mL