2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Donepezil-d5

Donepezil-d5  (Synonyms: E2020-d5)

Cat. No.: HY-14566S1 Purity: 99.30%
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Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

For research use only. We do not sell to patients.

Donepezil-d<sub>5</sub> Chemical Structure

Donepezil-d5 Chemical Structure

CAS No. : 1128086-25-8

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1 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Donepezil-d5:

Donepezil-d5 Related Antibodies

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Description

Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Donepezil-d5 Related Antibodies
Molecular Weight

384.52

Formula

C24H24D5NO3
CAS No.
Unlabeled CAS

120014-06-4
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (86.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 33.33 mg/mL (86.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2 mg/mL (5.20 mM; ultrasonic and warming and heat to 80°C)

H2O : 2 mg/mL (5.20 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6006 mL 13.0032 mL 26.0065 mL
5 mM 0.5201 mL 2.6006 mL 5.2013 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 2.6006 mL 13.0032 mL 26.0065 mL 65.0161 mL
5 mM 0.5201 mL 2.6006 mL 5.2013 mL 13.0032 mL
DMSO / DMSO 10 mM 0.2601 mL 1.3003 mL 2.6006 mL 6.5016 mL
15 mM 0.1734 mL 0.8669 mL 1.7338 mL 4.3344 mL
20 mM 0.1300 mL 0.6502 mL 1.3003 mL 3.2508 mL
25 mM 0.1040 mL 0.5201 mL 1.0403 mL 2.6006 mL
30 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1672 mL
40 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6254 mL
50 mM 0.0520 mL 0.2601 mL 0.5201 mL 1.3003 mL
60 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0836 mL
80 mM 0.0325 mL 0.1625 mL 0.3251 mL 0.8127 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Donepezil-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Donepezil-d51128086-25-8E2020-d5Cholinesterase (ChE)Inhibitorinhibitorinhibit

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