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  4. DOTA-cyclo(RGDfK)

DOTA-cyclo(RGDfK) is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy.

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DOTA-cyclo(RGDfK) Chemical Structure

DOTA-cyclo(RGDfK) Chemical Structure

CAS No. : 909024-55-1

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DOTA-cyclo(RGDfK) Related Antibodies

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Description

DOTA-cyclo(RGDfK) is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy[1].

Molecular Weight

990.07

Formula

C43H67N13O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{DOTA}-Arg-Gly-Asp-{d-Phe}-Lys
Sequence Shortening

{DOTA}-RGD-{d-Phe}-K
SMILES

O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCNC(CN2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)=O)[C@H]1CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (25.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0100 mL 5.0501 mL 10.1003 mL
5 mM 0.2020 mL 1.0100 mL 2.0201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0100 mL 5.0501 mL 10.1003 mL 25.2507 mL
5 mM 0.2020 mL 1.0100 mL 2.0201 mL 5.0501 mL
10 mM 0.1010 mL 0.5050 mL 1.0100 mL 2.5251 mL
15 mM 0.0673 mL 0.3367 mL 0.6734 mL 1.6834 mL
20 mM 0.0505 mL 0.2525 mL 0.5050 mL 1.2625 mL
25 mM 0.0404 mL 0.2020 mL 0.4040 mL 1.0100 mL
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DOTA-cyclo(RGDfK) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-cyclo(RGDfK)909024-55-1OthersInhibitorinhibitorinhibit

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