2. Antibody-drug Conjugate/ADC Related GPCR/G Protein Neuronal Signaling
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor
  4. DOTA-LM3

DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis.

For research use only. We do not sell to patients.

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DOTA-LM3 Chemical Structure

DOTA-LM3 Chemical Structure

CAS No. : 1192362-32-5

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Based on 1 publication(s) in Google Scholar

Other Forms of DOTA-LM3:

DOTA-LM3 Related Antibodies

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Description

DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis[1][2].

IC50 & Target

RDC Peptide

 

In Vitro

177Lu-DOTA-LM3 is tolerated. 177Lu-DOTA-LM3 in the whole body and in the kidneys, spleen, and metastases, resulting in higher mean absorbed organ and tumor doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-LM3 Related Antibodies
Molecular Weight

1550.16

Formula

C69H93ClN16O19S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DOTA-[p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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DOTA-LM3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-LM31192362-32-5Radionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorSSTRsSSTRsomatostatin receptorLM3p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2sotopically labeled177Lu-DOTA-LM368 Ga-DOTA-LM3biodistributionhigh tumor uptakegood tumor retentionsafetyDOTATOC-negative liver metastasespancreatic NETextensive tumor thrombosisInhibitorinhibitorinhibit

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