2. Antibody-drug Conjugate/ADC Related Others
  3. Radionuclide-Drug Conjugates (RDCs) Others
  4. DOTATATE acetate

DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DOTATATE acetate Chemical Structure

DOTATATE acetate Chemical Structure

CAS No. : 177943-89-4

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Based on 1 publication(s) in Google Scholar

Other Forms of DOTATATE acetate:

DOTATATE acetate Related Antibodies

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  • Biological Activity

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Description

DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4].

IC50 & Target

RDC Peptide

 

In Vivo

177Lu-DOTATATE shows excellent antitumor effects in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Formula

C65H90N14O19S2.xC2H4O2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 8.33 mg/mL (ultrasonic and warming and heat to 60°C)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 11.11 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

COA (263 KB) LCMS (103 KB) Elemental Analysis Report (122 KB)

Handling Instructions (2659 KB)
References
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DOTATATE acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTATATE177943-89-4Radionuclide-Drug Conjugates (RDCs)OthersradionuclidespositronemissiontomographyPETimagingpeptidereceptorradionuclidetherapyPRRTtumorInhibitorinhibitorinhibit

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DOTATATE acetate
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