2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand 18

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

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E3 ligase Ligand 18 Chemical Structure

E3 ligase Ligand 18 Chemical Structure

CAS No. : 2241669-88-3

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Based on 1 publication(s) in Google Scholar

E3 ligase Ligand 18 Related Antibodies

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Description

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

Molecular Weight

436.87

Formula

C17H17ClN6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@H](C(O)=O)CSC1=NC(C(N=C(N)N2)=O)=C2N1CC3=CC=C(Cl)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (57.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2890 mL 11.4451 mL 22.8901 mL
5 mM 0.4578 mL 2.2890 mL 4.5780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.22%

COA (251 KB) HNMR (145 KB) RP-HPLC (169 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2890 mL 11.4451 mL 22.8901 mL 57.2253 mL
5 mM 0.4578 mL 2.2890 mL 4.5780 mL 11.4451 mL
10 mM 0.2289 mL 1.1445 mL 2.2890 mL 5.7225 mL
15 mM 0.1526 mL 0.7630 mL 1.5260 mL 3.8150 mL
20 mM 0.1145 mL 0.5723 mL 1.1445 mL 2.8613 mL
25 mM 0.0916 mL 0.4578 mL 0.9156 mL 2.2890 mL
30 mM 0.0763 mL 0.3815 mL 0.7630 mL 1.9075 mL
40 mM 0.0572 mL 0.2861 mL 0.5723 mL 1.4306 mL
50 mM 0.0458 mL 0.2289 mL 0.4578 mL 1.1445 mL
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E3 ligase Ligand 18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 182241669-88-3Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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