E3 ligase Ligand 18

Cat. No.: HY-129653 Purity: 99.22%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

For research use only. We do not sell to patients.

E3 ligase Ligand 18 Chemical Structure

CAS No. : 2241669-88-3

Size	Price	Stock	Quantity
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 810	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP Fbxo3 RNF4 DCAF11

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

436.87

Formula

C₁₇H₁₇ClN₆O₄S

CAS No.

2241669-88-3

Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@H](C(O)=O)CSC1=NC(C(N=C(N)N2)=O)=C2N1CC3=CC=C(Cl)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (57.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2890 mL	11.4451 mL	22.8901 mL
5 mM	0.4578 mL	2.2890 mL	4.5780 mL
10 mM	0.2289 mL	1.1445 mL	2.2890 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.22%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (251 KB) HNMR (145 KB) RP-HPLC (169 KB)

Handling Instructions (2659 KB)

References

[1]. Heterocyclic compound. WO2018143403A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2890 mL	11.4451 mL	22.8901 mL	57.2253 mL
	5 mM	0.4578 mL	2.2890 mL	4.5780 mL	11.4451 mL
	10 mM	0.2289 mL	1.1445 mL	2.2890 mL	5.7225 mL
	15 mM	0.1526 mL	0.7630 mL	1.5260 mL	3.8150 mL
	20 mM	0.1145 mL	0.5723 mL	1.1445 mL	2.8613 mL
	25 mM	0.0916 mL	0.4578 mL	0.9156 mL	2.2890 mL
	30 mM	0.0763 mL	0.3815 mL	0.7630 mL	1.9075 mL
	40 mM	0.0572 mL	0.2861 mL	0.5723 mL	1.4306 mL
	50 mM	0.0458 mL	0.2289 mL	0.4578 mL	1.1445 mL