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  4. Syringin

Syringin  (Synonyms: Eleutheroside B)

Cat. No.: HY-N0824 Purity: 99.01%
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Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc.

For research use only. We do not sell to patients.

Syringin Chemical Structure

Syringin Chemical Structure

CAS No. : 118-34-3

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5 mg USD 55 In-stock
10 mg USD 88 In-stock
20 mg USD 154 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Syringin:

Syringin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Syringin

WB

    Syringin purchased from MedChemExpress. Usage Cited in: Immun Inflamm Dis. 2023 Feb;11(2):e775.  [Abstract]

    Syringin (50 mg/kg; i.p.; single daily for 7 days) reduces the level of Bax and cleaved caspase 3 as well as caspase 8 in I/R (ischemia/reperfusion) rats.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc[1].

    In Vitro

    Syringin (15 µM; 24 h) results in a marked decrease in the expression levels of hypertrophic markers and an inrease in the levels of α-MHC[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Syringin Related Antibodies

    RT-PCR[2]

    Cell Line: H9c2 cells
    Concentration: 15 µM
    Incubation Time: 24 h
    Result: Resulted in a marked decrease in the expression levels of hypertrophic markers and an inrease in the levels of α-MHC.
    In Vivo

    Syringin (10-40 mg/kg; orally active, daily, 12 weeks) significantly downregulates the expression of TRAF6, NF-κB and RANKL proteins levels, upregulated the expression of osteoprotegerin (OPG), PI3K and AKT levels, and subsequently increasing the OPG/RANKL ratio and inhibiting the osteoclastogenesis, finally promoting bone formation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sixty female ICR mice (24 g) bearing ovariectomized[1]
    Dosage: 10 mg/kg, 20 mg/kg and 40 mg/kg
    Administration: Orally active, daily, 12 weeks
    Result: Significantly improved the BMD, bone maximum load and trabecular bone microarchitecture in ovariectomized mice.
    Molecular Weight

    372.37

    Formula

    C17H24O9
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC(C(OC)=CC(/C=C/CO)=C2)=C2OC
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (268.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6855 mL 13.4275 mL 26.8550 mL
    5 mM 0.5371 mL 2.6855 mL 5.3710 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.01%

    COA (249 KB) HNMR (268 KB) LCMS (265 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6855 mL 13.4275 mL 26.8550 mL 67.1375 mL
    5 mM 0.5371 mL 2.6855 mL 5.3710 mL 13.4275 mL
    10 mM 0.2686 mL 1.3428 mL 2.6855 mL 6.7138 mL
    15 mM 0.1790 mL 0.8952 mL 1.7903 mL 4.4758 mL
    20 mM 0.1343 mL 0.6714 mL 1.3428 mL 3.3569 mL
    25 mM 0.1074 mL 0.5371 mL 1.0742 mL 2.6855 mL
    30 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2379 mL
    40 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6784 mL
    50 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3428 mL
    60 mM 0.0448 mL 0.2238 mL 0.4476 mL 1.1190 mL
    80 mM 0.0336 mL 0.1678 mL 0.3357 mL 0.8392 mL
    100 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6714 mL
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    Syringin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Syringin118-34-3Eleutheroside BAutophagyanti-osteoporosiscardiachypertrophyInhibitorinhibitorinhibit

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