1. PI3K/Akt/mTOR Anti-infection
  2. PI4K Parasite
  3. EDI048

EDI048 (compound 1.16) is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis.

For research use only. We do not sell to patients.

EDI048 Chemical Structure

EDI048 Chemical Structure

CAS No. : 2767264-57-1

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Based on 1 publication(s) in Google Scholar

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Description

EDI048 (compound 1.16) is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis[1].

Molecular Weight

476.91

Formula

C25H21ClN4O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(N(C)C(C2=CC3=C(C4=CC=C(C(NC)=O)C=C4)C=NN3C=C2)=O)=CC=C1Cl)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0968 mL 10.4842 mL 20.9683 mL
5 mM 0.4194 mL 2.0968 mL 4.1937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0968 mL 10.4842 mL 20.9683 mL 52.4208 mL
5 mM 0.4194 mL 2.0968 mL 4.1937 mL 10.4842 mL
10 mM 0.2097 mL 1.0484 mL 2.0968 mL 5.2421 mL
15 mM 0.1398 mL 0.6989 mL 1.3979 mL 3.4947 mL
20 mM 0.1048 mL 0.5242 mL 1.0484 mL 2.6210 mL
25 mM 0.0839 mL 0.4194 mL 0.8387 mL 2.0968 mL
30 mM 0.0699 mL 0.3495 mL 0.6989 mL 1.7474 mL
40 mM 0.0524 mL 0.2621 mL 0.5242 mL 1.3105 mL
50 mM 0.0419 mL 0.2097 mL 0.4194 mL 1.0484 mL
60 mM 0.0349 mL 0.1747 mL 0.3495 mL 0.8737 mL
80 mM 0.0262 mL 0.1311 mL 0.2621 mL 0.6553 mL
100 mM 0.0210 mL 0.1048 mL 0.2097 mL 0.5242 mL
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EDI048 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EDI048
Cat. No.:
HY-156685
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