2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-89

EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type.

For research use only. We do not sell to patients.

EGFR-IN-89 Chemical Structure

EGFR-IN-89 Chemical Structure

CAS No. : 2413029-40-8

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EGFR-IN-89 Related Antibodies

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Description

EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].

IC50 & Target[1]

EGFR19del/TM/CS

10.1 nM (IC50)

Molecular Weight

538.64

Formula

C26H31FN8O2S
CAS No.
SMILES

FC1=CC(NC2=NC(NC3=C(N(C)S(=O)(C)=O)C=CC=C3)=C4C(NC=C4)=N2)=CC=C1N5CCN(CC)CC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-89 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-892413029-40-8EGFREpidermal growth factor receptorErbB-1HER1antitumor activityDel19/T790M/C797S mutationfourth-generationInhibitorinhibitorinhibit

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