2. PI3K/Akt/mTOR Immunology/Inflammation
  3. PI3K Akt Toll-like Receptor (TLR)
  4. Egg oil

Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation.

For research use only. We do not sell to patients.

Egg oil Chemical Structure

Egg oil Chemical Structure

CAS No. : 8001-17-0

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25 mg USD 35 In-stock
50 mg USD 60 In-stock
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Egg oil Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

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Description

Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation[1][2][3][4].

In Vitro

Egg oil (0.1-0.8 mg/ml) reduces IL-8 secretion and exerts anti-inflammatory efficacy through Nrf2/NF-kB signaling pathway[2].
Egg oil (10-600 μg/ml) extracted from sea urchin attenuates 7β-OHC induced cytotoxicity, modulates activity of antioxidant enzyme and reduces production of MDA and CD, exhibits thus protective efficacy against neurodegenerative diseases[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Egg oil Related Antibodies

Cell Viability Assay[2]

Cell Line: Caco2
Concentration: 0.1-0.8 mg/ml
Incubation Time: 2 h
Result: Maintained cell viability.
In Vivo

Egg oil (150-600 mg/kg, i.g. for 16 weeks) extracted from Portunus trituberculatus improves insulin sensibility and hepatic glycogen synthesis, alleviates insulin resistance through activation of PI3K/Akt/Glu4 signaling in skeletal muscle and PI3K/Akt/GSK3β/GS pathway in the liver[1].
Egg oil (150-600 mg/kg, i.g. for 16 weeks) extracted from Portunus trituberculatus amliorates HFD-induced obesity in mice, restores the gut microbial dysbiosis and down-regulates the LPS/TLR4 pathway in liver and epididymal adipose[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat-diet feeding C57BL/6J mice[1][3]
Dosage: 150-600 mg/kg
Administration: i.g. for 16 weeks
Result: Reduced body weight, adipose weight gain, blood glucose and lipids.
Increased mRNA levels of PI3K, Akt, IPS1/2, Glu4, GSK3β and GS i muscle and liver.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Egg oil]
Structure Classification
Initial Source

egg
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥99.0%

COA (246 KB)

Handling Instructions (2659 KB)
References
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Egg oil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Egg oil8001-17-0PI3KAktToll-like Receptor (TLR)Phosphoinositide 3-kinasePKBProtein kinase BC57BL/6Jcheilitisulcerationobesityportunus trituberculatusCaco2158N Toll like receptor 4Inhibitorinhibitorinhibit

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