Emamectin B1a (Synonyms: L-656,748)

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Emamectin B1a (L-656,748) is a semisynthetic derivative of avermectin B1a that binds to GABA receptors (Ki=17.6 nM in rat brain membranes) and enhances GABA responses. Emamectin B1a acitivates GABAA receptors α1β1γ2, α1β2γ2, and α1β3γ2 with IC₅₀s of 57, 210, and 49.8 nM, respectively. Emamectin B1a also binds to glycine receptors, inhibiting glycine receptors with an IC₅₀=218 nM in rat spinal cord. Emamectin B1a (1.067 ng/mL) caused 90% mortality of S. exigua larvae in foliar spray bioassays and topical application, making it more toxic than avermectin B1.

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Emamectin B1a Chemical Structure

CAS No. : 121124-29-6

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1 mg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks

Estimated Time of Arrival: December 31

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Description

Emamectin B1a (L-656,748) is a semisynthetic derivative of avermectin B1a that binds to GABA receptors (Ki=17.6 nM in rat brain membranes) and enhances GABA responses. Emamectin B1a acitivates GABAA receptors α1β1γ2, α1β2γ2, and α1β3γ2 with IC₅₀s of 57, 210, and 49.8 nM, respectively. Emamectin B1a also binds to glycine receptors, inhibiting glycine receptors with an IC₅₀=218 nM in rat spinal cord. Emamectin B1a (1.067 ng/mL) caused 90% mortality of S. exigua larvae in foliar spray bioassays and topical application, making it more toxic than avermectin B1.

Molecular Weight
886.12

Formula
C₄₉H₇₅NO₁₃

CAS No.
121124-29-6

SMILES
CC[C@@H]([C@@H]1[C@@H](C)C=C[C@]2(C[C@@H]3C[C@@H](C/C=C(C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@H](NC)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C6CO[C@H]7[C@]\6(O)[C@H](C(O3)=O)C=C(C)[C@H]7O)O2)O1)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (269 KB) Handling Instructions (2659 KB)

References

[1]. Dawson, et al. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the g-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther. 295(3), 1051-1060 (2000).

[1]. Dawson, et al. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the g-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther. 295(3), 1051-1060 (2000).

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Emamectin B1a Related Classifications

Infection

Membrane Transporter/Ion Channel Neuronal Signaling

GABA Receptor

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emamectin B1a121124-29-6L-656,748GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

Description	Emamectin B1a (L-656,748) is a semisynthetic derivative of avermectin B1a that binds to GABA receptors (Ki=17.6 nM in rat brain membranes) and enhances GABA responses. Emamectin B1a acitivates GABAA receptors α1β1γ2, α1β2γ2, and α1β3γ2 with IC₅₀s of 57, 210, and 49.8 nM, respectively. Emamectin B1a also binds to glycine receptors, inhibiting glycine receptors with an IC₅₀=218 nM in rat spinal cord. Emamectin B1a (1.067 ng/mL) caused 90% mortality of S. exigua larvae in foliar spray bioassays and topical application, making it more toxic than avermectin B1.
Molecular Weight	886.12
Formula	C₄₉H₇₅NO₁₃
CAS No.	121124-29-6
SMILES	CC[C@@H]([C@@H]1[C@@H](C)C=C[C@]2(C[C@@H]3C[C@@H](C/C=C(C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@H](NC)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C6CO[C@H]7[C@]\6(O)[C@H](C(O3)=O)C=C(C)[C@H]7O)O2)O1)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Dawson, et al. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the g-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther. 295(3), 1051-1060 (2000).

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Emamectin B1a (Synonyms: L-656,748)

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Emamectin B1a Related Antibodies

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