2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. EMD 53998

EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias.

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EMD 53998 Chemical Structure

EMD 53998 Chemical Structure

CAS No. : 120223-04-3

Size Price Stock Quantity
5 mg USD 620 In-stock
10 mg USD 990 In-stock
25 mg USD 1980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of EMD 53998:

EMD 53998 Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias[1].

IC50 & Target

PDE3

 

Molecular Weight

425.50

Formula

C22H23N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(OC)=C(OC)C=C1)N2C3=CC=C(C(C(S4)C)=NNC4=O)C=C3CCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3502 mL 11.7509 mL 23.5018 mL
5 mM 0.4700 mL 2.3502 mL 4.7004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3502 mL 11.7509 mL 23.5018 mL 58.7544 mL
5 mM 0.4700 mL 2.3502 mL 4.7004 mL 11.7509 mL
10 mM 0.2350 mL 1.1751 mL 2.3502 mL 5.8754 mL
15 mM 0.1567 mL 0.7834 mL 1.5668 mL 3.9170 mL
20 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9377 mL
25 mM 0.0940 mL 0.4700 mL 0.9401 mL 2.3502 mL
30 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9585 mL
40 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4689 mL
50 mM 0.0470 mL 0.2350 mL 0.4700 mL 1.1751 mL
60 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9792 mL
80 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
100 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5875 mL
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EMD 53998 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EMD 53998120223-04-3EMD53998EMD-53998Phosphodiesterase (PDE)calcium sensitizerhuman myocardiumheart failureinotropic agentInhibitorinhibitorinhibit

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