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  5. Reynoutria japonica Houtt.
  6. Emodin 6-O-β-D-glucoside

Emodin 6-O-β-D-glucoside  (Synonyms: Glucoemodin)

Cat. No.: HY-N8126 Purity: 98.00%
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Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis.

For research use only. We do not sell to patients.

Emodin 6-O-β-D-glucoside Chemical Structure

Emodin 6-O-β-D-glucoside Chemical Structure

CAS No. : 34298-85-6

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Emodin 6-O-β-D-glucoside Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis[1].

In Vitro

Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability[1].
Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA[1].
Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs[1].
Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emodin 6-O-β-D-glucoside Related Antibodies

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 0~20 μM
Incubation Time: 24 hours
Result: Did not affect cell viability.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Inhibited high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin.

RT-PCR[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Resulted in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA.

Immunofluorescence[1]

Cell Line: HUVECs
Concentration: 10 μM
Incubation Time: 6 hours
Result: Resulted in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.
In Vivo

Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 0~9 mg/mouse
Administration: I.v.
Result: Markly inhibited peritoneal leakage of dye induced by high glucose.
Molecular Weight

432.38

Formula

C21H20O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3128 mL 11.5639 mL 23.1278 mL
5 mM 0.4626 mL 2.3128 mL 4.6256 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3128 mL 11.5639 mL 23.1278 mL 57.8195 mL
5 mM 0.4626 mL 2.3128 mL 4.6256 mL 11.5639 mL
10 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
15 mM 0.1542 mL 0.7709 mL 1.5419 mL 3.8546 mL
20 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
25 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
30 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
40 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
50 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
60 mM 0.0385 mL 0.1927 mL 0.3855 mL 0.9637 mL
80 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.5782 mL
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Emodin 6-O-β-D-glucoside Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emodin 6-O-β-D-glucoside34298-85-6GlucoemodinOthersactiveReynoutriajaponicapotentanti-inflammatorybarrierprotectivediabeticcomplicationsatherosclerosisInhibitorinhibitorinhibit

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