Emodin 6-O-β-D-glucoside  (Synonyms: Glucoemodin)

Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis^[1].

Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability^[1].
Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA^[1].
Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs^[1].
Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

432.38

C₂₁H₂₀O₁₀

34298-85-6

Solid

Light yellow to yellow

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13)=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Lee W, et al. Emodin-6-O-β-D--glucoside inhibits high-glucose-induced vascular inflammation. Inflammation. 2014;37(2):306-313.  [Content Brief]