ERK-IN-2 free base

Cat. No.: HY-133084A: FAQs
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ERK-IN-2 free base is a ERK2 inhibitor with an IC₅₀ value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM.

For research use only. We do not sell to patients.

ERK-IN-2 free base Chemical Structure

CAS No. : 2743576-55-6

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Other Forms of ERK-IN-2 free base:

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
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Description

ERK-IN-2 free base is a ERK2 inhibitor with an IC₅₀ value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM^[1].

IC₅₀ & Target^[1]

ERK2

1.8 nM (IC₅₀)

In Vitro

ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC₅₀ of 280 nM^[1].
ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC₅₀ values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ERK-IN-2 (1 mpk, p.o.; or 0.5 mpk, i.v.; rat) shows a t_1/2 of 0.4 h, and F% of 13%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

311.34

Formula

C₁₆H₁₇N₅O₂

CAS No.

2743576-55-6

SMILES

OCC1=C2C(NN=C2)=CC(NC(N[C@@H](C3=CC=CC=C3)C)=O)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. MRK-ERK Inhibitor and Negative Control.

ERK-IN-2 free base Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK-IN-22743576-55-6ERKExtracellular signal regulated kinasesCancerERKiInhibitorinhibitorinhibit

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