2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Estrogen receptor modulator 1

Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.

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Estrogen receptor modulator 1 Chemical Structure

Estrogen receptor modulator 1 Chemical Structure

CAS No. : 63676-22-2

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Based on 1 publication(s) in Google Scholar

Estrogen receptor modulator 1 Related Antibodies

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Description

Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].

In Vitro

Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2].
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Estrogen receptor modulator 1 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: T47D:A18/PKCα and T47D:A18-TAM1 cells
Concentration: 100 nM
Incubation Time: 10 days
Result: Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation.

Cell Viability Assay[2]

Cell Line: MCF-7:5C cells
Concentration: 100 nM
Incubation Time: 9 days
Result: Significantly inhibited the growth of MCF-7:5C cells.
In Vivo

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 week old athymic mice (Harlan-Sprague-Dawley)[2]
Dosage: 1.5 mg/animal
Administration: p.o. ; daily for 2 weeks
Result: Significantly reduced tumor volume.
Molecular Weight

242.29

Formula

C14H10O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (412.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1273 mL 20.6364 mL 41.2729 mL
5 mM 0.8255 mL 4.1273 mL 8.2546 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1273 mL 20.6364 mL 41.2729 mL 103.1821 mL
5 mM 0.8255 mL 4.1273 mL 8.2546 mL 20.6364 mL
10 mM 0.4127 mL 2.0636 mL 4.1273 mL 10.3182 mL
15 mM 0.2752 mL 1.3758 mL 2.7515 mL 6.8788 mL
20 mM 0.2064 mL 1.0318 mL 2.0636 mL 5.1591 mL
25 mM 0.1651 mL 0.8255 mL 1.6509 mL 4.1273 mL
30 mM 0.1376 mL 0.6879 mL 1.3758 mL 3.4394 mL
40 mM 0.1032 mL 0.5159 mL 1.0318 mL 2.5796 mL
50 mM 0.0825 mL 0.4127 mL 0.8255 mL 2.0636 mL
60 mM 0.0688 mL 0.3439 mL 0.6879 mL 1.7197 mL
80 mM 0.0516 mL 0.2580 mL 0.5159 mL 1.2898 mL
100 mM 0.0413 mL 0.2064 mL 0.4127 mL 1.0318 mL
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Estrogen receptor modulator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estrogen receptor modulator 163676-22-2Estrogen receptor modulator1Estrogen receptor modulator-1Estrogen Receptor/ERRtumorselectiveMCF-7:5CcellsbreastcancerathymicmiceInhibitorinhibitorinhibit

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