2. Neuronal Signaling GPCR/G Protein Metabolic Enzyme/Protease
  3. Dopamine Receptor Drug Metabolite
  4. Etilevodopa

Etilevodopa  (Synonyms: L-DOPA ethyl ester; Levodopa ethyl ester)

Cat. No.: HY-116016 Purity: 99.00%
COA Handling Instructions

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Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.

For research use only. We do not sell to patients.

Etilevodopa Chemical Structure

Etilevodopa Chemical Structure

CAS No. : 37178-37-3

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Based on 1 publication(s) in Google Scholar

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Etilevodopa Related Antibodies

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Description

Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].

In Vitro

Etilevodopa (L-Dopa ethyl ester) passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa[1].
Compared with standard Levodopa, Etilevodopa has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etilevodopa Related Antibodies
Molecular Weight

225.24

Formula

C11H15NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@H](C(OCC)=O)CC1=CC=C(C(O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 12 mg/mL (53.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4397 mL 22.1985 mL 44.3971 mL
5 mM 0.8879 mL 4.4397 mL 8.8794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.00%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.4397 mL 22.1985 mL 44.3971 mL 110.9927 mL
5 mM 0.8879 mL 4.4397 mL 8.8794 mL 22.1985 mL
10 mM 0.4440 mL 2.2199 mL 4.4397 mL 11.0993 mL
15 mM 0.2960 mL 1.4799 mL 2.9598 mL 7.3995 mL
20 mM 0.2220 mL 1.1099 mL 2.2199 mL 5.5496 mL
25 mM 0.1776 mL 0.8879 mL 1.7759 mL 4.4397 mL
30 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6998 mL
40 mM 0.1110 mL 0.5550 mL 1.1099 mL 2.7748 mL
50 mM 0.0888 mL 0.4440 mL 0.8879 mL 2.2199 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Etilevodopa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etilevodopa37178-37-3L-DOPA ethyl ester Levodopa ethyl esterDopamine ReceptorDrug MetaboliteprodrugesterasesgastrointestinaltractParkinsondiseasemotorfluctuationsCNSpenetrationInhibitorinhibitorinhibit

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