2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Dopamine Receptor Drug Metabolite
  4. Etilevodopa hydrochloride

Etilevodopa hydrochloride  (Synonyms: L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride)

Cat. No.: HY-116016A Purity: 99.40%
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Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.

For research use only. We do not sell to patients.

Etilevodopa hydrochloride Chemical Structure

Etilevodopa hydrochloride Chemical Structure

CAS No. : 39740-30-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 39 In-stock
Solution
10 mM * 1 mL in Water USD 39 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 60 In-stock
25 mg USD 125 In-stock
50 mg USD 200 In-stock
100 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Etilevodopa hydrochloride:

Etilevodopa hydrochloride Related Antibodies

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Description

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].

In Vitro

Etilevodopa (L-Dopa ethyl ester) hydrochloride passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa[1].
Compared with standard Levodopa, Etilevodopa hydrochloride has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etilevodopa hydrochloride Related Antibodies
Molecular Weight

261.70

Formula

C11H16ClNO4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@@H](CC1=CC=C(O)C(O)=C1)C(OCC)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (477.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8212 mL 19.1058 mL 38.2117 mL
5 mM 0.7642 mL 3.8212 mL 7.6423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (95.53 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8212 mL 19.1058 mL 38.2117 mL 95.5292 mL
5 mM 0.7642 mL 3.8212 mL 7.6423 mL 19.1058 mL
10 mM 0.3821 mL 1.9106 mL 3.8212 mL 9.5529 mL
15 mM 0.2547 mL 1.2737 mL 2.5474 mL 6.3686 mL
20 mM 0.1911 mL 0.9553 mL 1.9106 mL 4.7765 mL
25 mM 0.1528 mL 0.7642 mL 1.5285 mL 3.8212 mL
30 mM 0.1274 mL 0.6369 mL 1.2737 mL 3.1843 mL
40 mM 0.0955 mL 0.4776 mL 0.9553 mL 2.3882 mL
50 mM 0.0764 mL 0.3821 mL 0.7642 mL 1.9106 mL
60 mM 0.0637 mL 0.3184 mL 0.6369 mL 1.5922 mL
80 mM 0.0478 mL 0.2388 mL 0.4776 mL 1.1941 mL
100 mM 0.0382 mL 0.1911 mL 0.3821 mL 0.9553 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Etilevodopa hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etilevodopa39740-30-2L-DOPA ethyl esterLevodopa ethyl esterDopamine ReceptorDrug MetaboliteprodrugesterasesgastrointestinaltractParkinsondiseasemotorfluctuationsCNSpenetrationInhibitorinhibitorinhibit

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