2. Stem Cell/Wnt TGF-beta/Smad PROTAC
  3. TGF-beta/Smad PROTACs
  4. ETTAC-2

ETTAC-2 is a LRG1 PROTAC degrader. ETTAC-2 promotes ubiquitination and degradation of LRG1 (DC50 of 8.38 µM). ETTAC-2 inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated proteins. ETTAC-2 attenuates the progression of renal fibrosis.

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Custom Peptide Synthesis

ETTAC-2 Chemical Structure

ETTAC-2 Chemical Structure

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Based on 1 publication(s) in Google Scholar

ETTAC-2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

ETTAC-2 is a LRG1 PROTAC degrader. ETTAC-2 promotes ubiquitination and degradation of LRG1 (DC50 of 8.38 µM). ETTAC-2 inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated proteins. ETTAC-2 attenuates the progression of renal fibrosis[1].

Molecular Weight

1891.07

Formula

C83H123N23O26S
Appearance

Solid

Color

White to off-white

Sequence

Lenalidomide-(CC)-Gly-Gly-Glu-Ser-Tyr-Ser-Ala-Lys-His-Arg-Ile-Met-Leu-Thr
Sequence Shortening

Lenalidomide-(CC)-GGESYSAKHRIMLT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (52.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5288 mL 2.6440 mL 5.2880 mL
5 mM 0.1058 mL 0.5288 mL 1.0576 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5288 mL 2.6440 mL 5.2880 mL 13.2200 mL
5 mM 0.1058 mL 0.5288 mL 1.0576 mL 2.6440 mL
10 mM 0.0529 mL 0.2644 mL 0.5288 mL 1.3220 mL
15 mM 0.0353 mL 0.1763 mL 0.3525 mL 0.8813 mL
20 mM 0.0264 mL 0.1322 mL 0.2644 mL 0.6610 mL
25 mM 0.0212 mL 0.1058 mL 0.2115 mL 0.5288 mL
30 mM 0.0176 mL 0.0881 mL 0.1763 mL 0.4407 mL
40 mM 0.0132 mL 0.0661 mL 0.1322 mL 0.3305 mL
50 mM 0.0106 mL 0.0529 mL 0.1058 mL 0.2644 mL
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ETTAC-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ETTAC-2ETTAC2ETTAC 2TGF-beta/SmadPROTACsTransforming growth factor betarenal fibrosisInhibitorinhibitorinhibit

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