2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Cytotoxin Topoisomerase
  4. Exatecan-d5 mesylate

Exatecan-d5 mesylate  (Synonyms: DX8951f-d5; Exatecan-d5 mesylate; Deuterated labeled Exatecan mesylate)

Cat. No.: HY-13631AS Purity: 99.82%
COA Handling Instructions

Molarity Calculator

Exatecan-d5 (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].

For research use only. We do not sell to patients.

Exatecan-d<sub>5</sub> mesylate Chemical Structure

Exatecan-d5 mesylate Chemical Structure

CAS No. : 2819276-88-3

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 820 In-stock
25 mg USD 1640 In-stock
50 mg USD 2500 In-stock
100 mg USD 4000 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Exatecan-d5 mesylate:

Exatecan-d5 mesylate Related Antibodies

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Exatecan-d5 (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].

IC50 & Target[1]

Camptothecins

 

Molecular Weight

536.58

Formula

C25H21D5FN3O7S
CAS No.
Unlabeled CAS

169869-90-3
Appearance

Solid

Color

Yellow to brown

SMILES

O=S(C)(O)=O.O=C1[C@](O)(C(C([2H])([2H])[2H])([2H])[2H])C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 11.76 mg/mL (21.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 4.67 mg/mL (8.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2.6 mg/mL (4.85 mM; ultrasonic and warming and heat to 60°C)

H2O : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8637 mL 9.3183 mL 18.6365 mL
5 mM 0.3727 mL 1.8637 mL 3.7273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

COA (255 KB) HNMR (316 KB) RP-HPLC (206 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 1.8637 mL 9.3183 mL 18.6365 mL 46.5914 mL
DMSO / DMSO 5 mM 0.3727 mL 1.8637 mL 3.7273 mL 9.3183 mL
DMSO 10 mM 0.1864 mL 0.9318 mL 1.8637 mL 4.6591 mL
15 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1061 mL
20 mM 0.0932 mL 0.4659 mL 0.9318 mL 2.3296 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Exatecan-d5 mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Exatecan-d52819276-88-3DX8951f-d5Deuterated labeled ExatecanADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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