2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Firmonertinib

Firmonertinib  (Synonyms: Alflutinib; Furmonertinib; AST2818)

Cat. No.: HY-112870 Purity: 99.89%
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Firmonertinib (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.

For research use only. We do not sell to patients.

Firmonertinib Chemical Structure

Firmonertinib Chemical Structure

CAS No. : 1869057-83-9

Size Price Stock Quantity
5 mg USD 160 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 720 In-stock
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200 mg   Get quote  

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Based on 3 publication(s) in Google Scholar

Other Forms of Firmonertinib:

Firmonertinib Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

Firmonertinib (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation[1].

IC50 & Target[1]

EGFR

 

In Vitro

Firmonertinib is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Firmonertinib Related Antibodies
Clinical Trial
Molecular Weight

568.59

Formula

C28H31F3N8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (175.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7587 mL 8.7937 mL 17.5874 mL
5 mM 0.3517 mL 1.7587 mL 3.5175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7587 mL 8.7937 mL 17.5874 mL 43.9684 mL
5 mM 0.3517 mL 1.7587 mL 3.5175 mL 8.7937 mL
10 mM 0.1759 mL 0.8794 mL 1.7587 mL 4.3968 mL
15 mM 0.1172 mL 0.5862 mL 1.1725 mL 2.9312 mL
20 mM 0.0879 mL 0.4397 mL 0.8794 mL 2.1984 mL
25 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.7587 mL
30 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4656 mL
40 mM 0.0440 mL 0.2198 mL 0.4397 mL 1.0992 mL
50 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.8794 mL
60 mM 0.0293 mL 0.1466 mL 0.2931 mL 0.7328 mL
80 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5496 mL
100 mM 0.0176 mL 0.0879 mL 0.1759 mL 0.4397 mL
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Firmonertinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Firmonertinib1869057-83-9Alflutinib Furmonertinib AST2818AST2818AST 2818AST-2818EGFREpidermal growth factor receptorErbB-1HER1T790Mesistant mutationNSCLCcancerInhibitorinhibitorinhibit

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