Firmonertinib (Synonyms: Alflutinib; Furmonertinib; AST2818)

Cat. No.: HY-112870: FAQs
Data Sheet Handling Instructions

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Firmonertinib (Alflutinib) is a potent inhibitor of EGFR. Firmonertinib inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib has the potential for the research of cancer diseases, especially non-small cell lung cancer (NSCLC).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Firmonertinib mesylate) that retains the same biological activity.

For research use only. We do not sell to patients.

Firmonertinib Chemical Structure

CAS No. : 1869057-83-9

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Other In-stock Forms of Firmonertinib:

Firmonertinib mesylate

Other Forms of Firmonertinib:

Firmonertinib mesylate In-stock

3 Publications Citing Use of MCE Firmonertinib

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

EGFR

In Vitro

Firmonertinib is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

568.59

Formula

C₂₈H₃₁F₃N₈O₂

CAS No.

1869057-83-9

SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Y. Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.

Firmonertinib Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Firmonertinib1869057-83-9Alflutinib Furmonertinib AST2818AST2818AST 2818AST-2818EGFREpidermal growth factor receptorErbB-1HER1T790Mesistant mutationNSCLCcancerInhibitorinhibitorinhibit

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