2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Lipoxygenase COX
  4. Flobufen

Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis.

For research use only. We do not sell to patients.

Flobufen Chemical Structure

Flobufen Chemical Structure

CAS No. : 112344-52-2

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10 mg USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

Flobufen Related Antibodies

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

View All Isoforms
5-LOX 12-LOX 15-LOX

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

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Description

Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis[1][2][3].

IC50 & Target

COX; 5-LOX[1]
Molecular Weight

304.29

Formula

C17H14F2O3
CAS No.
Appearance

Solid

SMILES

FC1=C(C2=CC=C(C(CC(C)C(O)=O)=O)C=C2)C=CC(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (131.45 mM; ultrasonic and adjust pH to 9 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2863 mL 16.4317 mL 32.8634 mL
5 mM 0.6573 mL 3.2863 mL 6.5727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2863 mL 16.4317 mL 32.8634 mL 82.1585 mL
5 mM 0.6573 mL 3.2863 mL 6.5727 mL 16.4317 mL
10 mM 0.3286 mL 1.6432 mL 3.2863 mL 8.2158 mL
15 mM 0.2191 mL 1.0954 mL 2.1909 mL 5.4772 mL
20 mM 0.1643 mL 0.8216 mL 1.6432 mL 4.1079 mL
25 mM 0.1315 mL 0.6573 mL 1.3145 mL 3.2863 mL
30 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7386 mL
40 mM 0.0822 mL 0.4108 mL 0.8216 mL 2.0540 mL
50 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.6432 mL
60 mM 0.0548 mL 0.2739 mL 0.5477 mL 1.3693 mL
80 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0270 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8216 mL
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Flobufen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flobufen112344-52-2VUFB 16066VUFB16066VUFB-16066LipoxygenaseCOXLOXCyclooxygenaseNSAIDsarthritisanti-inflammatory agentsInhibitorinhibitorinhibit

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