2. Immunology/Inflammation Apoptosis
  3. COX Apoptosis
  4. Flurbiprofen-d5

Flurbiprofen-d5  (Synonyms: dl-Flurbiprofen-d5)

Cat. No.: HY-10582S1 Purity: 99.76%
COA Handling Instructions

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Flurbiprofen-d5 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

For research use only. We do not sell to patients.

Flurbiprofen-d<sub>5</sub> Chemical Structure

Flurbiprofen-d5 Chemical Structure

CAS No. : 215175-76-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Flurbiprofen-d5:

Flurbiprofen-d5 Related Antibodies

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COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

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Description

Flurbiprofen-d5 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flurbiprofen-d5 Related Antibodies
Molecular Weight

249.29

Formula

C15H8D5FO2
CAS No.
Unlabeled CAS

5104-49-4
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C=CC(C(C)C(O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (401.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (401.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0114 mL 20.0570 mL 40.1139 mL
5 mM 0.8023 mL 4.0114 mL 8.0228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.76%

COA (249 KB) HNMR (124 KB) RP-HPLC (803 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 4.0114 mL 20.0570 mL 40.1139 mL 100.2848 mL
5 mM 0.8023 mL 4.0114 mL 8.0228 mL 20.0570 mL
10 mM 0.4011 mL 2.0057 mL 4.0114 mL 10.0285 mL
15 mM 0.2674 mL 1.3371 mL 2.6743 mL 6.6857 mL
20 mM 0.2006 mL 1.0028 mL 2.0057 mL 5.0142 mL
25 mM 0.1605 mL 0.8023 mL 1.6046 mL 4.0114 mL
30 mM 0.1337 mL 0.6686 mL 1.3371 mL 3.3428 mL
40 mM 0.1003 mL 0.5014 mL 1.0028 mL 2.5071 mL
50 mM 0.0802 mL 0.4011 mL 0.8023 mL 2.0057 mL
60 mM 0.0669 mL 0.3343 mL 0.6686 mL 1.6714 mL
80 mM 0.0501 mL 0.2507 mL 0.5014 mL 1.2536 mL
100 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
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Flurbiprofen-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flurbiprofen-d5215175-76-1dl-Flurbiprofen-d5COXApoptosisCyclooxygenaseInhibitorinhibitorinhibit

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