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FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects.

For research use only. We do not sell to patients.

FSC231 Chemical Structure

FSC231 Chemical Structure

CAS No. : 1215849-96-9

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5 mg USD 140 In-stock
10 mg USD 225 In-stock
25 mg USD 440 In-stock
50 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

FSC231 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects[1].

IC50 & Target

PICK1[1].
In Vitro

FSC231 (50 μM) blocks binding between GluR2 and PICK1 in COS7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSC231 Related Antibodies
In Vivo

FSC231 (78.40 μg/kg in total, daily, seven times, i.p., 3 h before Paclitaxel) alleviates the Paclitaxel (HY-B0015)‐induced neuralgia of rats[1].
FSC231 (39.2μg/kg/day, i.p., for 4 weeks) inhibits the development of diabetic cardiomyopathy in rats by inhibiting ROS generation and apoptosis partly via PICK1/eNOS/cGMP pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Paclitaxel (HY-B0015)‐induced neuralgia of rats[1]
Dosage: 78.40 μg/kg in total
Administration: i.p., daily, seven times, completed at 3 h before Paclitaxel
Result: Reversed the changes of inflammatory cytokines (IL‐6, TNF‐α and IL‐10).
Inhibited the phosphorylation levels of GSK‐3β and ERK1/2.
Molecular Weight

313.14

Formula

C13H10Cl2N2O3
CAS No.
Appearance

Solid

SMILES

O=C(OCC)NC(/C(C#N)=C/C1=CC=C(Cl)C(Cl)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (159.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1935 mL 15.9673 mL 31.9346 mL
5 mM 0.6387 mL 3.1935 mL 6.3869 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1935 mL 15.9673 mL 31.9346 mL 79.8365 mL
5 mM 0.6387 mL 3.1935 mL 6.3869 mL 15.9673 mL
10 mM 0.3193 mL 1.5967 mL 3.1935 mL 7.9836 mL
15 mM 0.2129 mL 1.0645 mL 2.1290 mL 5.3224 mL
20 mM 0.1597 mL 0.7984 mL 1.5967 mL 3.9918 mL
25 mM 0.1277 mL 0.6387 mL 1.2774 mL 3.1935 mL
30 mM 0.1064 mL 0.5322 mL 1.0645 mL 2.6612 mL
40 mM 0.0798 mL 0.3992 mL 0.7984 mL 1.9959 mL
50 mM 0.0639 mL 0.3193 mL 0.6387 mL 1.5967 mL
60 mM 0.0532 mL 0.2661 mL 0.5322 mL 1.3306 mL
80 mM 0.0399 mL 0.1996 mL 0.3992 mL 0.9980 mL
100 mM 0.0319 mL 0.1597 mL 0.3193 mL 0.7984 mL
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FSC231 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSC2311215849-96-9FSC 231FSC-231Othersneuralgiadiabetic cardiomyopathyCOS7Inhibitorinhibitorinhibit

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