2. Metabolic Enzyme/Protease
  3. Fat Mass and Obesity-associated Protein (FTO)
  4. FTO-IN-8

FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity.

For research use only. We do not sell to patients.

FTO-IN-8 Chemical Structure

FTO-IN-8 Chemical Structure

CAS No. : 2640366-38-5

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10 mg USD 380 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
100 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

FTO-IN-8 Related Antibodies

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Description

FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity[1].

In Vitro

FTO-IN-8 (FTO-43) (0-50 μM, 24-72 h) inhibits the proliferation of cancer cells with no cytotoxicity to normal colonic cells[1].
FTO-IN-8 (FTO-43) can increase m6A and m6Am levels and inhibits Wnt/PI3K-Akt signaling in gastric cancer AGS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FTO-IN-8 Related Antibodies

Cell Viability Assay[1]

Cell Line: AGS, SNU16, and KATOIII cell lines
Concentration: 0-50 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited the growth of SNU16, KATOIII and AGS with the EC50 values of 17.7 μM, 35.9 μM and 20.3 μM, respectively.
Molecular Weight

346.85

Formula

C19H23ClN2O2
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

ClC1=CC=CC=C1C2=CC=C(CNCC3(N4CCCC4)COC3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (288.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8831 mL 14.4155 mL 28.8309 mL
5 mM 0.5766 mL 2.8831 mL 5.7662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8831 mL 14.4155 mL 28.8309 mL 72.0773 mL
5 mM 0.5766 mL 2.8831 mL 5.7662 mL 14.4155 mL
10 mM 0.2883 mL 1.4415 mL 2.8831 mL 7.2077 mL
15 mM 0.1922 mL 0.9610 mL 1.9221 mL 4.8052 mL
20 mM 0.1442 mL 0.7208 mL 1.4415 mL 3.6039 mL
25 mM 0.1153 mL 0.5766 mL 1.1532 mL 2.8831 mL
30 mM 0.0961 mL 0.4805 mL 0.9610 mL 2.4026 mL
40 mM 0.0721 mL 0.3604 mL 0.7208 mL 1.8019 mL
50 mM 0.0577 mL 0.2883 mL 0.5766 mL 1.4415 mL
60 mM 0.0481 mL 0.2403 mL 0.4805 mL 1.2013 mL
80 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9010 mL
100 mM 0.0288 mL 0.1442 mL 0.2883 mL 0.7208 mL
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FTO-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTO-IN-82640366-38-5Fat Mass and Obesity-associated Protein (FTO)FTON6-methyladenosine demethylasem 6 Aanti-cancergastric cancerInhibitorinhibitorinhibit

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