2. Immunology/Inflammation
  3. Galectin
  4. Galectin-3/galectin-8-IN-1

Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis.

For research use only. We do not sell to patients.

Galectin-3/galectin-8-IN-1 Chemical Structure

Galectin-3/galectin-8-IN-1 Chemical Structure

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5 mg USD 430 In-stock
10 mg USD 690 In-stock
25 mg USD 1375 In-stock
50 mg USD 2200 In-stock
100 mg USD 3500 In-stock
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Based on 1 publication(s) in Google Scholar

Galectin-3/galectin-8-IN-1 Related Antibodies

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Galectin-1 Galectin-3 Galectin-4 Galectin-8

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Description

Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis[1].

IC50 & Target

Kd: 4.12 μM (Galectin-3) and 6.04 μM (Galectin-8C)[1]
Molecular Weight

518.39

Formula

C22H13Cl2N3O4S2
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(N1)=CC2=C1C=CC(OC3=CC=C(Cl)C(Cl)=C3)=C2)NS(=O)(C4=CC=C5N=CSC5=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (48.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9290 mL 9.6452 mL 19.2905 mL
5 mM 0.3858 mL 1.9290 mL 3.8581 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9290 mL 9.6452 mL 19.2905 mL 48.2262 mL
5 mM 0.3858 mL 1.9290 mL 3.8581 mL 9.6452 mL
10 mM 0.1929 mL 0.9645 mL 1.9290 mL 4.8226 mL
15 mM 0.1286 mL 0.6430 mL 1.2860 mL 3.2151 mL
20 mM 0.0965 mL 0.4823 mL 0.9645 mL 2.4113 mL
25 mM 0.0772 mL 0.3858 mL 0.7716 mL 1.9290 mL
30 mM 0.0643 mL 0.3215 mL 0.6430 mL 1.6075 mL
40 mM 0.0482 mL 0.2411 mL 0.4823 mL 1.2057 mL
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Galectin-3/galectin-8-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galectin-3/galectin-8-IN-1GalectinmigrationMRC-5lungfibroblastcancerfibrosisInhibitorinhibitorinhibit

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