2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Apoptosis
  4. Gemtuzumab ozogamicin

Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic drug Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML).

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Gemtuzumab ozogamicin Chemical Structure

Gemtuzumab ozogamicin Chemical Structure

CAS No. : 220578-59-6

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Gemtuzumab ozogamicin Related Antibodies

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Description

Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic drug Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML)[1][2].

In Vitro

Gemtuzumab ozogamicin (1-250 ng/mL ; 72 hours) has cell cytotoxicity in CD33-positive cells[1].
Gemtuzumab ozogamicin is an ADC. After binding of the antibody to CD33 and subsequent internalization, Calicheamicin mediates cytotoxicity to CD33-positive myeloid cells primarily through induction of DNA damage and subsequent apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gemtuzumab ozogamicin Related Antibodies

Cell Viability Assay[1]

Cell Line: CD33-positive and CD33-deficient cells (HL60, HL60R, Kasumi-1, MV4-11, MV4-11R, primary CD34-positive HSPCs and primary AML blasts)
Concentration: 0, 1, 5, 10, 25, 50, 100, 250 ng/mL
Incubation Time: 72 hours
Result: Wildtype HL60 exhibited the highest sensitivity to GO (IC50=1.37 ng/mL), and almost all HL60 cells died at 5 ng/mL concentration.
HL60R, Kasumi-1, MV4-11 and MV4-11R showed similar sensitivity, with IC50s of 2.28, 3.19, 3.63 and 5.36 ng/mL, respectively.
IC50 in CD33-negative HL60R, Kasumi-1, MV4-11 and MV4-11R cells also increased significantly to 95.53, 50.78, 72.74 and 66.8 ng/mL, respectively.
Clinical Trial
Molecular Weight

151000 (average)

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Gemtuzumab ozogamicin]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation

Purity: 98.0%

SDS (251 KB)

COA (231 KB)

Handling Instructions (2659 KB)
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Gemtuzumab ozogamicin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemtuzumab ozogamicin220578-59-6Antibody-Drug Conjugates (ADCs)ApoptosisAntibody-Drug ConjugatesIgG4CD33antibioticacute myeloid leukemiaAMLInhibitorinhibitorinhibit

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