FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

Homo sapiens

Gene ID: 10023 | Gene type: protein coding

About FRAT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,319,271-97,321,915 (from NCBI)

This gene has 2 transcripts (splice variants), 63 orthologues and 1 paralogue.

Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

FRAT1 Products(1)

mRNA	Protein	Name
NM_005479.4	NP_005470.2	proto-oncogene FRAT1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	10481074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10481074	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10428961	GOA
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	12556519	GOA
involved in positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	12556519	GOA
involved in regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	12223487	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12223487	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12223487	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRAT1 Protein Structure

GSK-3_bind

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

proto-oncogene FRAT1

FRAT-1

FRAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRAT1	Q92837	GSK3A	Homo sapiens	P49840	Pull Down	10481074
Intra	FRAT1	Q92837	GSK3A	Homo sapiens	P49840	Anti Tag CoIP	26496610
Intra	FRAT1	Q92837	GSK3B	Homo sapiens	P49841	X-Ray Diffraction	11738041
Intra	FRAT1	Q92837	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05090	FRAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FRAT1	VGNC	VGNC:72816
Mus musculus	FRAT1	MGD	MGI:109450
Bos taurus	FRAT1	VGNC	VGNC:55951
Rattus norvegicus	FRAT1	RGD	RGD:9147096

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