2. Gene
  3. ABI2 - abl interactor 2 Gene

ABI2 - abl interactor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB

Gene ID: 10152 | Gene type: protein coding

About ABI2

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,328,394-203,432,169 (from NCBI)

This gene has 24 transcripts (splice variants), 201 orthologues and 2 paralogues. Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues.

Summary

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein Ligase binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including filopodium tip; lamellipodium; and nucleoplasm. Part of SCAR complex. Is active in adherens junction. Colocalizes with actin filament. [provided by Alliance of Genome Resources, Apr 2022]

ABI2 Products(88)

mRNA Protein Name
NM_001282925.3 NP_001269854.1 abl interactor 2 isoform a
NM_001282926.3 NP_001269855.1 abl interactor 2 isoform b
NM_001282927.2 NP_001269856.1 abl interactor 2 isoform d
NM_001282932.2 NP_001269861.1 abl interactor 2 isoform e
NM_001375662.1 NP_001362591.1 abl interactor 2 isoform f
NM_001375663.1 NP_001362592.1 abl interactor 2 isoform f
NM_001375664.1 NP_001362593.1 abl interactor 2 isoform g
NM_001375665.1 NP_001362594.1 abl interactor 2 isoform g
NM_001375666.1 NP_001362595.1 abl interactor 2 isoform h
NM_001375667.1 NP_001362596.1 abl interactor 2 isoform h
NM_001375668.1 NP_001362597.1 abl interactor 2 isoform i
NM_001375669.1 NP_001362598.1 abl interactor 2 isoform i
NM_001375670.1 NP_001362599.1 abl interactor 2 isoform j
NM_001375671.1 NP_001362600.1 abl interactor 2 isoform k
NM_001375672.1 NP_001362601.1 abl interactor 2 isoform l
NM_001375673.1 NP_001362602.1 abl interactor 2 isoform m
NM_001375674.1 NP_001362603.1 abl interactor 2 isoform n
NM_001375675.1 NP_001362604.1 abl interactor 2 isoform o
NM_001375676.1 NP_001362605.1 abl interactor 2 isoform p
NM_001375677.1 NP_001362606.1 abl interactor 2 isoform q
NM_001375678.1 NP_001362607.1 abl interactor 2 isoform r
NM_001375679.1 NP_001362608.1 abl interactor 2 isoform s
NM_001375680.1 NP_001362609.1 abl interactor 2 isoform t
NM_001375681.1 NP_001362610.1 abl interactor 2 isoform u
NM_001375682.1 NP_001362611.1 abl interactor 2 isoform v
NM_001375683.1 NP_001362612.1 abl interactor 2 isoform w
NM_001375684.1 NP_001362613.1 abl interactor 2 isoform x
NM_001375685.1 NP_001362614.1 abl interactor 2 isoform y
NM_001375686.1 NP_001362615.1 abl interactor 2 isoform z
NM_001375687.1 NP_001362616.1 abl interactor 2 isoform aa
NM_001375688.1 NP_001362617.1 abl interactor 2 isoform bb
NM_001375689.1 NP_001362618.1 abl interactor 2 isoform cc
NM_001375690.1 NP_001362619.1 abl interactor 2 isoform dd
NM_001375691.1 NP_001362620.1 abl interactor 2 isoform ee
NM_001375692.1 NP_001362621.1 abl interactor 2 isoform ff
NM_001375693.1 NP_001362622.1 abl interactor 2 isoform gg
NM_001375695.1 NP_001362624.1 abl interactor 2 isoform hh
NM_001375696.1 NP_001362625.1 abl interactor 2 isoform ii
NM_001375698.1 NP_001362627.1 abl interactor 2 isoform jj
NM_001375699.1 NP_001362628.1 abl interactor 2 isoform kk
NM_001375702.1 NP_001362631.1 abl interactor 2 isoform ll
NM_001375704.1 NP_001362633.1 abl interactor 2 isoform mm
NM_001375706.1 NP_001362635.1 abl interactor 2 isoform nn
NM_001375707.1 NP_001362636.1 abl interactor 2 isoform oo
NM_001375708.1 NP_001362637.1 abl interactor 2 isoform pp
NM_001375709.1 NP_001362638.1 abl interactor 2 isoform qq
NM_001375710.1 NP_001362639.1 abl interactor 2 isoform rr
NM_001375711.1 NP_001362640.1 abl interactor 2 isoform ss
NM_001375712.1 NP_001362641.1 abl interactor 2 isoform tt
NM_001375714.1 NP_001362643.1 abl interactor 2 isoform uu
NM_001375717.1 NP_001362646.1 abl interactor 2 isoform vv
NM_001375719.1 NP_001362648.1 abl interactor 2 isoform ww
NM_001375721.1 NP_001362650.1 abl interactor 2 isoform xx
NM_001375722.1 NP_001362651.1 abl interactor 2 isoform yy
NM_001375723.1 NP_001362652.1 abl interactor 2 isoform zz
NM_001375724.1 NP_001362653.1 abl interactor 2 isoform aaa
NM_001375725.1 NP_001362654.1 abl interactor 2 isoform bbb
NM_001375726.1 NP_001362655.1 abl interactor 2 isoform ccc
NM_001375727.1 NP_001362656.1 abl interactor 2 isoform ddd
NM_001375728.1 NP_001362657.1 abl interactor 2 isoform eee
NM_001375729.1 NP_001362658.1 abl interactor 2 isoform fff
NM_001375730.1 NP_001362659.1 abl interactor 2 isoform ggg
NM_001375731.1 NP_001362660.1 abl interactor 2 isoform hhh
NM_001375732.1 NP_001362661.1 abl interactor 2 isoform iii
NM_001375733.1 NP_001362662.1 abl interactor 2 isoform jjj
NM_001375734.1 NP_001362663.1 abl interactor 2 isoform kkk
NM_001375735.1 NP_001362664.1 abl interactor 2 isoform lll
NM_001375736.1 NP_001362665.1 abl interactor 2 isoform mmm
NM_001375737.1 NP_001362666.1 abl interactor 2 isoform nnn
NM_001375738.1 NP_001362667.1 abl interactor 2 isoform ooo
NM_001375739.1 NP_001362668.1 abl interactor 2 isoform ppp
NM_001375740.1 NP_001362669.1 abl interactor 2 isoform rrr
NM_001375741.1 NP_001362670.1 abl interactor 2 isoform sss
NM_001375742.1 NP_001362671.1 abl interactor 2 isoform ttt
NM_001375743.1 NP_001362672.1 abl interactor 2 isoform uuu
NM_001375744.1 NP_001362673.1 abl interactor 2 isoform vvv
NM_001375745.1 NP_001362674.1 abl interactor 2 isoform www
NM_001375746.1 NP_001362675.1 abl interactor 2 isoform xxx
NM_001375747.1 NP_001362676.1 abl interactor 2 isoform yyy
NM_001375748.1 NP_001362677.1 abl interactor 2 isoform zzz
NM_001375749.1 NP_001362678.1 abl interactor 2 isoform aaaa
NM_001375750.1 NP_001362679.1 abl interactor 2 isoform bbbb
NM_001375751.1 NP_001362680.1 abl interactor 2 isoform cccc
NM_001375752.1 NP_001362681.1 abl interactor 2 isoform dddd
NM_001375753.1 NP_001362682.1 abl interactor 2 isoform eeee
NM_001375754.1 NP_001362683.1 abl interactor 2 isoform d
NM_001375755.1 NP_001362684.1 abl interactor 2 isoform qqq
NM_005759.7 NP_005750.4 abl interactor 2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
7590236 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
7590236 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
17101133 GOA
contributes to small GTPase binding IDA
IDA: Inferred from direct assay
21107423 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
18632609 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Rac protein signal transduction IDA
IDA: Inferred from direct assay
21107423 GOA
involved in mitophagy IDA
IDA: Inferred from direct assay
38081847 GOA
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17101133 GOA
involved in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
21107423 GOA
involved in positive regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
21107423 GOA
involved in zonula adherens assembly IMP
IMP: Inferred from mutant phenotype
15572692 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCAR complex IDA
IDA: Inferred from direct assay
21107423 GOA
colocalizes with actin filament IDA
IDA: Inferred from direct assay
15572692 GOA
is active in adherens junction IDA
IDA: Inferred from direct assay
15572692 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17101133 GOA
located in filopodium tip IDA
IDA: Inferred from direct assay
11516653 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
11516653 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABI2 Protein Structure

Abi_HHR

Abi_HHR: Abl-interactor HHR (93 - 170)

SH3_9

SH3_9: Variant SH3 domain (458 - 506)

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  • 513 a.a.
Protein Preferred Names Protein Names

abl interactor 2

abelson interactor 2

ABI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ABI2 Q9NYB9 KRT13 Homo sapiens A1A4E9
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra
ABI2 Q9NYB9 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 EIF3S3 Homo sapiens Q6IB98
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 EIF3S3 Homo sapiens Q6IB98
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 EIF3S3 Homo sapiens Q6IB98
Y2H Array
25416956
Intra
ABI2 Q9NYB9 KIAA1217 Homo sapiens Q5T5P2-6
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 KIAA1217 Homo sapiens Q5T5P2-6
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 VARS2 Homo sapiens Q5ST30-4
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 VARS2 Homo sapiens Q5ST30-4
Y2H Array
25416956
Intra
ABI2 Q9NYB9 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
ABI2 Q9NYB9 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
ABI2 Q9NYB9 EGLN3 Homo sapiens Q9H6Z9
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 EGLN3 Homo sapiens Q9H6Z9
Y2H Array
25416956
Intra
ABI2 Q9NYB9 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
ABI2 Q9NYB9 PRKAA2 Homo sapiens P54646
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra
ABI2 Q9NYB9 PRAM1 Homo sapiens Q96QH2
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 PRAM1 Homo sapiens Q96QH2
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 PRAM1 Homo sapiens Q96QH2
Y2H Array
25416956
Intra
ABI2 Q9NYB9 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra
ABI2 Q9NYB9 HNRNPK Homo sapiens P61978
Y2H Array
29892012
Intra
ABI2 Q9NYB9 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 ARHGAP32 Homo sapiens A7KAX9
Y2H Array
25416956
Intra
ABI2 Q9NYB9 WIPF1 Homo sapiens O43516
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 NUP62 Homo sapiens P37198
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 NUP62 Homo sapiens P37198
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 NUP62 Homo sapiens P37198
Y2H Array
25416956
Intra
ABI2 Q9NYB9 NUP62 Homo sapiens P37198
Y2H Array
31515488
Intra
ABI2 Q9NYB9 STAM2 Homo sapiens O75886
Y2H Array
25416956
Intra
ABI2 Q9NYB9 STAM2 Homo sapiens O75886
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 STAM2 Homo sapiens O75886
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 ABL1 Homo sapiens P00519
Anti Tag CoIP
33961781
Intra
ABI2 Q9NYB9 PPIF Homo sapiens P30405
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 PRR16 Homo sapiens Q569H4
Y2H Array
29892012
Intra
ABI2 Q9NYB9 PRR16 Homo sapiens Q569H4
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 PRR16 Homo sapiens Q569H4
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 PRR16 Homo sapiens Q569H4
Y2H Array
25416956
Intra
ABI2 Q9NYB9 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
Intra
ABI2 Q9NYB9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
Intra
ABI2 Q9NYB9 MRPL44 Homo sapiens Q9H9J2
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
ABI2 Q9NYB9 EFS Homo sapiens O43281
Y2H Array
31515488
Intra
ABI2 Q9NYB9 EFS Homo sapiens O43281
Y2H Array
25416956
Intra
ABI2 Q9NYB9 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
ABI2 Q9NYB9 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
ABI2 Q9NYB9 HGS Homo sapiens O14964
Y2H Array
25416956
Intra
ABI2 Q9NYB9 DTNB Homo sapiens O60941
Y2H Array
31515488
Intra
ABI2 Q9NYB9 KRT20 Homo sapiens P35900
Y2H Pooling
16189514
Intra
ABI2 Q9NYB9 TRIM32 Homo sapiens Q13049
Y2H Array
31515488
Intra
ABI2 Q9NYB9 TRIM32 Homo sapiens Q13049
Anti Tag CoIP
33961781
Intra
ABI2 Q9NYB9 TRIM32 Homo sapiens Q13049
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 TRIM32 Homo sapiens Q13049
Y2H Array
25416956
Intra
ABI2 Q9NYB9 ARMC7 Homo sapiens Q9H6L4
Y2H Array
25416956
Intra
ABI2 Q9NYB9 ARMC7 Homo sapiens Q9H6L4
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
X-Ray Diffraction
21107423
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
Anti Tag CoIP
33961781
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
GMS
24439376
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
GMS
19363480
Intra
ABI2 Q9NYB9 NCKAP1 Homo sapiens Q9Y2A7
GMS
19363480
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
GMS
21107423
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
ITC
24439376
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
Solution Sedimentation
19363480
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
X-Ray Diffraction
24439376
Intra
ABI2 Q9NYB9 NCKAP1 Homo sapiens Q9Y2A7
Solution Sedimentation
19363480
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
Ion Exchange Chrom
21107423
Intra
ABI2 Q9NYB9 NCKAP1 Homo sapiens Q9Y2A7
Ion Exchange Chrom
21107423
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
TEM
21107423
Intra
ABI2 Q9NYB9 WASF1 Homo sapiens Q92558
FPS
24439376
Intra
ABI2 Q9NYB9 IFT20 Homo sapiens Q8IY31
Y2H Pooling
16189514
Intra
ABI2 Q9NYB9 GCC1 Homo sapiens Q96CN9
Y2H Array
25416956
Intra
ABI2 Q9NYB9 CRX Homo sapiens O43186
Y2H Array
25416956
Intra
ABI2 Q9NYB9 VASP Homo sapiens P50552
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 VASP Homo sapiens P50552
Y2H Array
25416956
Intra
ABI2 Q9NYB9 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
Intra
ABI2 Q9NYB9 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
25416956
Intra
ABI2 Q9NYB9 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
ABI2 Q9NYB9 IHO1 Homo sapiens Q8IYA8
Y2H Array
25416956
Intra
ABI2 Q9NYB9 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
ABI2 Q9NYB9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
ABI2 Q9NYB9 CCHCR1 Homo sapiens Q8TD31
Y2H Array
29892012
Cross: Cross-species interaction Intra: Intraspecies interaction

ABI2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83095 ABI2 Antibody (YA2840) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h

Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency

Muscular Dystrophy Hutterite Type

Sarcotubular Myopathy

Limb-Girdle Muscular Dystrophy Type 2h
Cataract 3, Multiple Types

Cataract 3 Multiple Types

CTRCT3

Cca2

Cataract, Congenital, Cerulean Type, 2

Cataract 3, Multiple Types, With Or Without Microcornea

Cataract 3 Multiple Types With Or Without Microcornea

Congenital Cerulean Type Cataract 2

Congenital Cataract Blue Dot Type 2

Congenital Cataract Cerulean Type 2

Cspc

Sutural Cataract With Punctate And Cerulean Opacities
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00099 ABI2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ABI2 VGNC VGNC:59487
Macaca mulatta ABI2 VGNC VGNC:69518
Canis familiaris ABI2 VGNC VGNC:37475
Bos taurus ABI2 VGNC VGNC:25506
Rattus norvegicus ABI2 RGD RGD:628771
Mus musculus ABI2 MGD MGI:106913