WASF2 - WASP family member 2 Gene

Homo sapiens

Also known as IMD2; SCAR2; WASF4; WAVE2; dJ393P12.2

Gene ID: 10163 | Gene type: protein coding

About WASF2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,404,230-27,490,167 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 43.4), ovary (RPKM 33.8) and 25 other tissues.

Summary

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

WASF2 Products(2)

mRNA	Protein	Name
NM_001201404.3	NP_001188333.1	actin-binding protein WASF2 isoform 2
NM_006990.5	NP_008921.1	actin-binding protein WASF2 isoform 1

WASF2 Protein Structure

WH2

0
100
200
300
400
498 a.a.

Protein Preferred Names

Protein Names

actin-binding protein WASF2

WAS protein family member 2

WASF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WASF2	Q9Y6W5	ABL1	Homo sapiens	P00519	Anti Tag CoIP	35271311
Intra	WASF2	Q9Y6W5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	WASF2	Q9Y6W5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	WASF2	Q9Y6W5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	WASF2	Q9Y6W5	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	WASF2	Q9Y6W5	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	WASF2	Q9Y6W5	BAIAP2	Homo sapiens	Q9UQB8-4	Far-WB	11130076
Intra	WASF2	Q9Y6W5	BAIAP2	Homo sapiens	Q9UQB8-4	Anti Tag CoIP	11130076
Intra	WASF2	Q9Y6W5	BAIAP2	Homo sapiens	Q9UQB8-4	Pull Down	11130076

Cross: Cross-species interaction Intra: Intraspecies interaction

WASF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83327	WAVE 2 Antibody (YA3072)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Coronin-1a Deficiency

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15743	WASF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WASF2	VGNC	VGNC:48334
Felis catus	WASF2	VGNC	VGNC:67003
Rattus norvegicus	WASF2	RGD	RGD:1307299
Mus musculus	WASF2	MGD	MGI:1098641
Bos taurus	WASF2	VGNC	VGNC:36866
Macaca mulatta	WASF2	VGNC	VGNC:78781

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