2. Gene
  3. RBM7 - RNA binding motif protein 7 Gene

RBM7 - RNA binding motif protein 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10179 | Gene type: protein coding

About RBM7

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,400,666-114,410,607 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 12.9), urinary bladder (RPKM 8.3) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Involved in snRNA catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RBM7 Products(5)

mRNA Protein Name
NM_001286045.2 NP_001272974.1 RNA-binding protein 7 isoform a
NM_001286046.2 NP_001272975.1 RNA-binding protein 7 isoform c
NM_001286047.2 NP_001272976.1 RNA-binding protein 7 isoform c
NM_001286048.2 NP_001272977.1 RNA-binding protein 7 isoform c
NM_016090.4 NP_057174.1 RNA-binding protein 7 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
25189701 GOA
enables 14-3-3 protein binding IPI
IPI: Inferred from physical interaction
25189701 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
25578728 GOA
enables RNA binding IMP
IMP: Inferred from mutant phenotype
25189701 GOA
enables pre-mRNA intronic binding IDA
IDA: Inferred from direct assay
25578728 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16263084 GOA
enables snRNA binding IDA
IDA: Inferred from direct assay
25852104 GOA
Biological Process GO Annotation Evidence Reference Source
involved in snRNA catabolic process IMP
IMP: Inferred from mutant phenotype
25852104 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in nucleolus IDA
IDA: Inferred from direct assay
21855801 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16263084 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21855801 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM7 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 81)

  • 0
  • 100
  • 200
  • 266 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 7

RBM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RBM7 Q9Y580 ZCCHC8 Homo sapiens Q6NZY4
Pull Down
27905398
Intra
RBM7 Q9Y580 ZCCHC8 Homo sapiens Q6NZY4
Anti Tag CoIP
26496610
Intra
RBM7 Q9Y580 ZCCHC8 Homo sapiens Q6NZY4
Anti Tag CoIP
33961781
Intra
RBM7 Q9Y580 ZCCHC8 Homo sapiens Q6NZY4
Anti Tag CoIP
28514442
Intra
RBM7 Q9Y580 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra
RBM7 Q9Y580 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra
RBM7 Q9Y580 SF3B2 Homo sapiens Q13435
Pull Down
27905398
Intra
RBM7 Q9Y580 SF3B2 Homo sapiens Q13435
Anti Tag CoIP
33961781
Intra
RBM7 Q9Y580 SF3B2 Homo sapiens Q13435
Anti Tag CoIP
28514442
Intra
RBM7 Q9Y580 EVI5L Homo sapiens Q96CN4
Y2H Prey Pooling
32296183
Intra
RBM7 Q9Y580 EVI5L Homo sapiens Q96CN4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2

THES2
Pontocerebellar Hypoplasia, Type 1d

PCH1D

Pontocerebellar Hypoplasia Type 1d

Pontocerebellar Hypoplasia 1d

Doid:0112323

Hypoplasia, Pontocerebellar, Type 1d
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11758 RBM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RBM7 MGD MGI:1914260
Macaca mulatta RBM7 VGNC VGNC:101388
Rattus norvegicus RBM7 RGD RGD:1308017