2. Gene
  3. PRMT3 - protein arginine methyltransferase 3 Gene

PRMT3 - protein arginine methyltransferase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HRMT1L3

Gene ID: 10196 | Gene type: protein coding

About PRMT3

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,387,716-20,509,338 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 7.5), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

PRMT3 Products(6)

mRNA Protein Name
XM_047426227.1 XP_047282183.1 protein arginine N-methyltransferase 3 isoform X1
NM_001145166.2 NP_001138638.1 protein arginine N-methyltransferase 3 isoform 2
NM_005788.4 NP_005779.1 protein arginine N-methyltransferase 3 isoform 1
XM_011519836.3 XP_011518138.1 protein arginine N-methyltransferase 3 isoform X2
XM_047426228.1 XP_047282184.1 protein arginine N-methyltransferase 3 isoform X3
NM_001145167.2 NP_001138639.1 protein arginine N-methyltransferase 3 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables methyltransferase activity IDA
IDA: Inferred from direct assay
18573314 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18573314 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
18573314 GOA
involved in negative regulation of retinoic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
33495566 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
33495566 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT3 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (255 - 328)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 3

HMT1 hnRNP methyltransferase-like 3

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

PRMT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRMT3 O60678 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
32296183
Intra
PRMT3 O60678 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra
PRMT3 O60678 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
PRMT3 O60678 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra
PRMT3 O60678 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
PRMT3 O60678 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra
PRMT3 O60678 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
PRMT3 O60678 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PRMT3 O60678 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PRMT3 O60678 RPS2 Homo sapiens P15880
TAP
24981860
Intra
PRMT3 O60678 RPS2 Homo sapiens P15880
Validated Y2H
32296183
Intra
PRMT3 O60678 RPS2 Homo sapiens P15880
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRMT3 Proteins

Cat. No. Product Name Accession Purity
HY-P76551 PRMT3 Protein, Human (His) O60678-1 (C2-Q531) ≥95%

PRMT3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81986 PRMT3 Antibody (YA1731) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2

DRS2

Robinow, Autosomal Dominant Syndrome, Type 2
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-128717 GSK3368715 Inhibitor / Phase 1
HY-128717B GSK3368715 trihydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-19715 SGC707 Inhibitor 98.08% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-159732 PRMT3-IN-4 Inhibitor / Unkown
HY-159728 PROTAC PRMT3 degrader 1 Degrader / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-110158 UNC2327 Inhibitor 99.70% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRMT3 VGNC VGNC:64359
Mus musculus PRMT3 MGD MGI:1919224
Rattus norvegicus PRMT3 RGD RGD:620413
Bos taurus PRMT3 VGNC VGNC:33349
Canis familiaris PRMT3 VGNC VGNC:44997
Others PRMT3 NCBI