2. Gene
  3. PRMT3 - protein arginine methyltransferase 3 Gene

PRMT3 - protein arginine methyltransferase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HRMT1L3

Gene ID: 10196 | Gene type: protein coding

About PRMT3

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,387,716-20,509,338 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 7.5), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

PRMT3 Products(6)

mRNA Protein Name
XM_047426227.1 XP_047282183.1 protein arginine N-methyltransferase 3 isoform X1
NM_001145166.2 NP_001138638.1 protein arginine N-methyltransferase 3 isoform 2
NM_005788.4 NP_005779.1 protein arginine N-methyltransferase 3 isoform 1
XM_011519836.3 XP_011518138.1 protein arginine N-methyltransferase 3 isoform X2
XM_047426228.1 XP_047282184.1 protein arginine N-methyltransferase 3 isoform X3
NM_001145167.2 NP_001138639.1 protein arginine N-methyltransferase 3 isoform 3

PRMT3 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (255 - 328)

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  • 531 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 3

HMT1 hnRNP methyltransferase-like 3

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

Recombinant PRMT3 Proteins

Cat. No. Product Name Accession Purity
HY-P76551 PRMT3 Protein, Human (His) O60678-1 (C2-Q531) ≥95%

Related Diseases

Diseases Alias
Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2

DRS2

Robinow, Autosomal Dominant Syndrome, Type 2
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-19715 SGC707 Inhibitor 98.08% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-159728 PROTAC PRMT3 degrader 1 Degrader / Unkown
HY-110158 UNC2327 Inhibitor 99.70% Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-159732 PRMT3-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRMT3 VGNC VGNC:64359
Mus musculus PRMT3 MGD MGI:1919224
Rattus norvegicus PRMT3 RGD RGD:620413
Bos taurus PRMT3 VGNC VGNC:33349
Canis familiaris PRMT3 VGNC VGNC:44997
Others PRMT3 NCBI