EIF1 - eukaryotic translation initiation factor 1 Gene

Homo sapiens

Also known as A121; ISO1; SUI1; EIF-1; EIF1A

Gene ID: 10209 | Gene type: protein coding

About EIF1

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,688,885-41,692,668 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 681.9), fat (RPKM 274.0) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

EIF1 Products(1)

mRNA	Protein	Name
NM_005801.4	NP_005792.1	eukaryotic translation initiation factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22813744	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	14600024	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	12435632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	22156057	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	9732867	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
part of eukaryotic 43S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of eukaryotic 48S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of multi-eIF complex	IDA IDA: Inferred from direct assay	9732867	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1 Protein Structure

SUI1

0
100
113 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 1

protein translation factor SUI1 homolog

EIF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF1	P41567	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF1	P41567	EIF3A	Homo sapiens	Q14152	Pull Down	23623729

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700519	EIF1 Protein, Human (GST)	P41567 (M1-F113)	≥95%

Related Diseases

Diseases

Alias

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Mehmo Syndrome

Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity	MEHMO
Mrxs20	Mrxs25
X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome	Mrxsbrk
Mental Retardation, X-Linked, Syndromic 20	Mental Retardation, X-Linked, Syndromic 25
Mental Retardation, X-Linked, Syndromic, Borck Type	Syndromic X-Linked Mental Retardation 20
Syndromic X-Linked Mental Retardation 25	Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity
X-Linked Mehmo Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04237	EIF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04238	EIF1AX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04239	EIF1AY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04240	EIF1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EIF1	VGNC	VGNC:40253
Bos taurus	EIF1	VGNC	VGNC:57141
Rattus norvegicus	EIF1	RGD	RGD:1306308
Mus musculus	EIF1	MGD	MGI:105125
Others	EIF1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.