EIF3C - eukaryotic translation initiation factor 3 subunit C Gene

Homo sapiens

Also known as EIF3CL; EIF3S8; eIF3-p110

Gene ID: 8663 | Gene type: protein coding

About EIF3C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,688,558-28,735,730 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues.

Summary

Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3C Products(5)

mRNA	Protein	Name
NM_001037808.2	NP_001032897.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001199142.1	NP_001186071.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001267574.2	NP_001254503.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001286478.1	NP_001273407.1	eukaryotic translation initiation factor 3 subunit C isoform b
NM_003752.5	NP_003743.1	eukaryotic translation initiation factor 3 subunit C isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10504338	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	8995409	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of mRNA binding	IPI IPI: Inferred from physical interaction	24092755	GOA
involved in positive regulation of translation	IPI IPI: Inferred from physical interaction	24092755	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3C Protein Structure

eIF-3c_N

PCI

0
200
400
600
800
913 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit C

cell migration-inducing protein 17

EIF3C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3C	Q99613	UBE3A	Homo sapiens	Q05086-2	Anti Tag CoIP	29426014
Intra	EIF3C	Q99613	EIF1AX	Homo sapiens	P47813	Pull Down	23623729
Intra	EIF3C	Q99613	EIF3E	Homo sapiens	P60228	Y2H	10504338
Intra	EIF3C	Q99613	EIF3E	Homo sapiens	P60228	SLCA	18599441
Intra	EIF3C	Q99613	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	33961781
Intra	EIF3C	Q99613	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	33961781
Cross	EIF3C	Q99613	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	EIF3C	Q99613	EIF1	Homo sapiens	P41567	Pull Down	23623729
Intra	EIF3C	Q99613	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04259	EIF3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF3C	MGD	MGI:1926966
Rattus norvegicus	EIF3C	RGD	RGD:1308871

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