EIF3A - eukaryotic translation initiation factor 3 subunit A Gene

Homo sapiens

Also known as EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta

Gene ID: 8661 | Gene type: protein coding

About EIF3A

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,033,670-119,080,817 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3A Products(1)

mRNA	Protein	Name
NM_003750.4	NP_003741.1	eukaryotic translation initiation factor 3 subunit A

EIF3A Protein Structure

PCI

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600
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1200
1382 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit A

EIF3, p180 subunit

EIF3A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3A	Q14152	EIF1AX	Homo sapiens	P47813	Pull Down	23623729
Intra	EIF3A	Q14152	KRT7	Homo sapiens	P08729	Y2H	11169732
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	GMS	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	3D-EM	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Ion Exchange Chrom	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Anti Bait CoIP	17353931
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	TEM	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	SLCA	18599441
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	GMS	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	SLCA	18599441
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	3D-EM	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	TEM	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	Ion Exchange Chrom	23623729
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Anti Bait CoIP	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Pull Down	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Y2H	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	SLCA	18599441
Intra	EIF3A	Q14152	UPF1	Homo sapiens	Q92900-2	Anti Bait CoIP	18423202
Intra	EIF3A	Q14152	EIF1	Homo sapiens	P41567	Pull Down	23623729

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

Diphyllobothriasis

Diphyllobothrium Infection	Fish Tapeworm
Bothriocephalosis	Infection By Bothriocephalus
Fish Tapeworm Infection	Dibothriocephalus Anaemia
Dibothriocephaliasis	Broad Tapeworm Infection
Bothriocephaliasis	Dibothriocephalus
Intestinal Diphyllobothriasis	Diphyllobothrium Infestation
Dibothriocephalus Infestation	Bothriocephalus Infestation
Adult Diphyllobothrium Infection	Tapeworm Anaemia
Infection By Diphyllobothrium Larvae

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04257	EIF3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3A	RGD	RGD:1307269
Felis catus	EIF3A	VGNC	VGNC:61780
Bos taurus	EIF3A	VGNC	VGNC:28392
Canis familiaris	EIF3A	VGNC	VGNC:40268
Mus musculus	EIF3A	MGD	MGI:95301

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