FLOT1 - flotillin 1 Gene

Homo sapiens

Gene ID: 10211 | Gene type: protein coding

About FLOT1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,727,709-30,742,687 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 279 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 66.3), heart (RPKM 56.6) and 25 other tissues.

Summary

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

FLOT1 Products(2)

mRNA	Protein	Name
NM_001318875.2	NP_001305804.1	flotillin-1 isoform 2
NM_005803.4	NP_005794.1	flotillin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	24612608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15469992	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in dsRNA transport	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	21119006	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in plasma membrane raft assembly	IMP IMP: Inferred from mutant phenotype	21399631	GOA
acts upstream of positive effect plasma membrane raft organization	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23319823	GOA
involved in positive regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in regulation of neurotransmitter uptake	IDA IDA: Inferred from direct assay	21399631	GOA
involved in regulation of neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	21399631	GOA
NOT involved in regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	25204797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	24046456	GOA
NOT located in apical plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23983584	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	25468996	GOA
located in centriolar satellite	IDA IDA: Inferred from direct assay	18000879	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24046456	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23983584	GOA
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	21399631	GOA
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	21399631	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21399631	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
part of flotillin complex	IDA IDA: Inferred from direct assay	21399631	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	24046456	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	15469992	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	18000879	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21399631	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21696602	GOA
located in uropod	IDA IDA: Inferred from direct assay	21696602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLOT1 Protein Structure

Band_7

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

flotillin-1

integral membrane component of caveolae

Related Diseases

Diseases

Alias

Mycobacterium Marinum

Mycobacterium Marinum Infection	Fish Tank Granuloma
M. Marinum

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6	CDCBM6
Cdcbm56	Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04982	FLOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FLOT1	RGD	RGD:70991
Felis catus	FLOT1	VGNC	VGNC:62294
Macaca mulatta	FLOT1	VGNC	VGNC:72674
Bos taurus	FLOT1	VGNC	VGNC:29036
Canis familiaris	FLOT1	VGNC	VGNC:40903
Mus musculus	FLOT1	MGD	MGI:1100500

Name
Email *

	Sorry, but the email address you supplied was invalid.