2. Gene
  3. HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNRPR; NEDDFSB; hnRNP-R

Gene ID: 10236 | Gene type: protein coding

About HNRNPR

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,304,688-23,344,284 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 236 orthologues, 24 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 17.7), appendix (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-Fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

HNRNPR Products(7)

mRNA Protein Name
NM_001102397.3 NP_001095867.1 heterogeneous nuclear ribonucleoprotein R isoform 4
NM_001102398.3 NP_001095868.1 heterogeneous nuclear ribonucleoprotein R isoform 1
NM_001102399.3 NP_001095869.1 heterogeneous nuclear ribonucleoprotein R isoform 3
NM_001297620.2 NP_001284549.1 heterogeneous nuclear ribonucleoprotein R isoform 5
NM_001297621.2 NP_001284550.1 heterogeneous nuclear ribonucleoprotein R isoform 7
NM_001297622.2 NP_001284551.1 heterogeneous nuclear ribonucleoprotein R isoform 6
NM_005826.5 NP_005817.1 heterogeneous nuclear ribonucleoprotein R isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
9421497 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
9421497 GOA
located in nucleus IDA
IDA: Inferred from direct assay
31079900 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPR Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (167 - 231)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (248 - 309)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (343 - 404)

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  • 633 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein R

HNRNPR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HNRNPR O43390 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
Intra
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Prey Pooling
25416956
Intra
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Pooling
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HNRNPR Proteins

Cat. No. Product Name Accession Purity
HY-P73920 HNRNPR Protein, Human (sf9, His-GST) O43390-2 (A2-K636) ≥95%

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities

NEDDFSB
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06277 HNRNPR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPR RGD RGD:631348
Felis catus HNRNPR VGNC VGNC:67612
Mus musculus HNRNPR MGD MGI:1891692
Canis familiaris HNRNPR VGNC VGNC:41735
Bos taurus HNRNPR VGNC VGNC:29899
Macaca mulatta HNRNPR VGNC VGNC:73499
Others HNRNPR NCBI