PIAS3 - protein inhibitor of activated STAT 3 Gene

Homo sapiens

Also known as ZMIZ5

Gene ID: 10401 | Gene type: protein coding

About PIAS3

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,848,522-145,859,081 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 17.3), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 Ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

PIAS3 Products(1)

mRNA	Protein	Name
NM_006099.3	NP_006090.2	E3 SUMO-protein ligase PIAS3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	15507434	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11060035	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein sumoylation	IDA IDA: Inferred from direct assay	24651376	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	17696781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS3 Protein Structure

PINIT

zf-MIZ

0
100
200
300
400
500
628 a.a.

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS3

E3 SUMO-protein transferase PIAS3

PIAS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PIAS3	Q9Y6X2	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	PIAS3	Q9Y6X2	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	PIAS3	Q9Y6X2	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	PIAS3	Q9Y6X2	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PIAS3	Q9Y6X2	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PIAS3	Q9Y6X2	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PIAS3	Q9Y6X2	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PIAS3	Q9Y6X2	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PIAS3	Q9Y6X2	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PIAS3	Q9Y6X2	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	PIAS3	Q9Y6X2	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	PIAS3	Q9Y6X2	MBD1	Homo sapiens	Q9UIS9	Pull Down	17066076
Intra	PIAS3	Q9Y6X2	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PIAS3	Q9Y6X2	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	PIAS3	Q9Y6X2	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Unilateral Focal Polymicrogyria

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10475	PIAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIAS3	MGD	MGI:1913126
Macaca mulatta	PIAS3	VGNC	VGNC:75811
Rattus norvegicus	PIAS3	RGD	RGD:708413
Bos taurus	PIAS3	VGNC	VGNC:32857
Felis catus	PIAS3	VGNC	VGNC:64160
Canis familiaris	PIAS3	VGNC	VGNC:44521

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