2. Gene
  3. PPIE - peptidylprolyl isomerase E Gene

PPIE - peptidylprolyl isomerase E Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CYP33; CYP-33

Gene ID: 10450 | Gene type: protein coding

About PPIE

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,738,882-39,763,914 (from NCBI)

This gene has 15 transcripts (splice variants), 189 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved Cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

PPIE Products(4)

mRNA Protein Name
NM_001195007.2 NP_001181936.1 peptidyl-prolyl cis-trans isomerase E isoform 4
NM_001319293.2 NP_001306222.1 peptidyl-prolyl cis-trans isomerase E isoform 5
NM_006112.4 NP_006103.1 peptidyl-prolyl cis-trans isomerase E isoform 1
NM_203456.3 NP_982281.1 peptidyl-prolyl cis-trans isomerase E isoform 2

PPIE Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (8 - 78)

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (143 - 298)

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  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase E

PPIase E

Recombinant PPIE Proteins

Cat. No. Product Name Accession Purity
HY-P71225 PPIE Protein, Human (His) Q9UNP9 (M1-V301) ≥95%

Related Diseases

Diseases Alias
Voyeurism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10950 PPIE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPIE RGD RGD:1311411
Macaca mulatta PPIE VGNC VGNC:81509
Canis familiaris PPIE VGNC VGNC:44852
Bos taurus PPIE VGNC VGNC:55661
Mus musculus PPIE MGD MGI:1917118
Others PPIE NCBI