PPIE - peptidylprolyl isomerase E Gene

Homo sapiens

Also known as CYP33; CYP-33

Gene ID: 10450 | Gene type: protein coding

About PPIE

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,738,882-39,763,914 (from NCBI)

This gene has 15 transcripts (splice variants), 189 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved Cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

PPIE Products(4)

mRNA	Protein	Name
NM_001195007.2	NP_001181936.1	peptidyl-prolyl cis-trans isomerase E isoform 4
NM_001319293.2	NP_001306222.1	peptidyl-prolyl cis-trans isomerase E isoform 5
NM_006112.4	NP_006103.1	peptidyl-prolyl cis-trans isomerase E isoform 1
NM_203456.3	NP_982281.1	peptidyl-prolyl cis-trans isomerase E isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	18258190	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	18258190	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	18258190	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11313484	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19932913	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11313484	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11313484	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIE Protein Structure

RRM_1

Pro_isomerase

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase E

PPIase E

PPIE Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PPIE	Q9UNP9	S	Human coronavirus NL63	Q6Q1S2	P8 Filamentous Phage	34799561
Cross	PPIE	Q9UNP9	S	Human coronavirus NL63	Q6Q1S2	Phage Display	37100772
Intra	PPIE	Q9UNP9	AQR	Homo sapiens	O60306	TAP	24981860
Intra	PPIE	Q9UNP9	AQR	Homo sapiens	O60306	Anti Tag CoIP	33961781
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Validated Y2H	25416956
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	33961781
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Y2H Array	25416956
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	22365833
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Y2H Pooling	16189514
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	TAP	24981860
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Y2H	22365833
Intra	PPIE	Q9UNP9	XAB2	Homo sapiens	Q9HCS7	Y2H Prey Pooling	25416956
Intra	PPIE	Q9UNP9	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PPIE	Q9UNP9	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PPIE	Q9UNP9	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PPIE	Q9UNP9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PPIE	Q9UNP9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PPIE	Q9UNP9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PPIE	Q9UNP9	KMT2A	Homo sapiens	Q03164	GMS	20541251

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71225	PPIE Protein, Human (His)	Q9UNP9 (M1-V301)	≥95%

Related Diseases

Diseases

Alias

Voyeurism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10950	PPIE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPIE	RGD	RGD:1311411
Macaca mulatta	PPIE	VGNC	VGNC:81509
Canis familiaris	PPIE	VGNC	VGNC:44852
Bos taurus	PPIE	VGNC	VGNC:55661
Mus musculus	PPIE	MGD	MGI:1917118
Others	PPIE	NCBI

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