AQR - aquarius intron-binding spliceosomal factor Gene

Homo sapiens

Also known as IBP160; fSAP164

Gene ID: 9716 | Gene type: protein coding

About AQR

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,851,782-34,969,742 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 10.7), thyroid (RPKM 9.9) and 25 other tissues.

Summary

Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

AQR Products(1)

mRNA	Protein	Name
NM_014691.3	NP_055506.1	RNA helicase aquarius

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' RNA helicase activity	IDA IDA: Inferred from direct assay	25599396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	25599396	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQR Protein Structure

AAA_11

AAA_12

0
300
600
900
1200
1485 a.a.

Protein Preferred Names

Protein Names

RNA helicase aquarius

aquarius homolog

AQR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AQR	O60306	ISY1	Homo sapiens	Q9ULR0	Pull Down	25599396
Intra	AQR	O60306	ISY1	Homo sapiens	Q9ULR0	Crosslink	25599396
Intra	AQR	O60306	ISY1	Homo sapiens	Q9ULR0	Ion Exchange Chrom	25599396
Intra	AQR	O60306	ISY1	Homo sapiens	Q9ULR0	Light Scattering	25599396
Intra	AQR	O60306	ISY1	Homo sapiens	Q9ULR0	GMS	25599396
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	Pull Down	25599396
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	GMS	25599396
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	3D-EM	28502770
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	Light Scattering	25599396
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	Crosslink	25599396
Intra	AQR	O60306	XAB2	Homo sapiens	Q9HCS7	Ion Exchange Chrom	25599396
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	Ion Exchange Chrom	25599396
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	Pull Down	25599396
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	GMS	25599396
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	Y2H	22365833
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	Light Scattering	25599396
Intra	AQR	O60306	ZNF830	Homo sapiens	Q96NB3	Crosslink	25599396
Intra	AQR	O60306	PPIE	Homo sapiens	Q9UNP9	Light Scattering	25599396
Intra	AQR	O60306	PPIE	Homo sapiens	Q9UNP9	GMS	25599396
Intra	AQR	O60306	PPIE	Homo sapiens	Q9UNP9	Pull Down	25599396
Intra	AQR	O60306	PPIE	Homo sapiens	Q9UNP9	Crosslink	25599396
Intra	AQR	O60306	PPIE	Homo sapiens	Q9UNP9	Ion Exchange Chrom	25599396
Intra	AQR	O60306	WDR83	Homo sapiens	Q9BRX9	Y2H	22365833

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 13

RP13	Retinitis Pigmentosa-13
Retinitis Pigmentosa, Type 13

Balanoposthitis

Balanitis Due To Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00882	AQR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AQR	MGD	MGI:1276102
Macaca mulatta	AQR	VGNC	VGNC:69925
Felis catus	AQR	VGNC	VGNC:59861
Bos taurus	AQR	VGNC	VGNC:26052
Rattus norvegicus	AQR	RGD	RGD:1306223
Canis familiaris	AQR	VGNC	VGNC:38022

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