2. Gene
  3. AQR - aquarius intron-binding spliceosomal factor Gene

AQR - aquarius intron-binding spliceosomal factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IBP160; fSAP164

Gene ID: 9716 | Gene type: protein coding

About AQR

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,851,782-34,969,742 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 10.7), thyroid (RPKM 9.9) and 25 other tissues.

Summary

Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

AQR Products(1)

mRNA Protein Name
NM_014691.3 NP_055506.1 RNA helicase aquarius
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3'-5' RNA helicase activity IDA
IDA: Inferred from direct assay
25599396 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
25599396 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQR Protein Structure

AAA_11

AAA_11: AAA domain (803 - 1106)

AAA_12

AAA_12: AAA domain (1115 - 1305)

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  • 1200
  • 1485 a.a.
Protein Preferred Names Protein Names

RNA helicase aquarius

aquarius homolog

Related Diseases

Diseases Alias
Retinitis Pigmentosa 13

RP13

Retinitis Pigmentosa-13

Retinitis Pigmentosa, Type 13
Balanoposthitis

Balanitis Due To Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00882 AQR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AQR MGD MGI:1276102
Macaca mulatta AQR VGNC VGNC:69925
Felis catus AQR VGNC VGNC:59861
Bos taurus AQR VGNC VGNC:26052
Rattus norvegicus AQR RGD RGD:1306223
Canis familiaris AQR VGNC VGNC:38022