CCT2 - chaperonin containing TCP1 subunit 2 Gene

Homo sapiens

Also known as CCTB; 99D8.1; PRO1633; CCT-beta; HEL-S-100n; TCP-1-beta

Gene ID: 10576 | Gene type: protein coding

About CCT2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,585,459-69,601,570 (from NCBI)

This gene has 14 transcripts (splice variants), 214 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 107.5), bone marrow (RPKM 41.1) and 24 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CCT2 Products(2)

mRNA	Protein	Name
NM_001198842.2	NP_001185771.1	T-complex protein 1 subunit beta isoform 2
NM_006431.3	NP_006422.1	T-complex protein 1 subunit beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21753002	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of or within chaperone-mediated protein complex assembly	IMP IMP: Inferred from mutant phenotype	20080638	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
involved in positive regulation of telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive effect scaRNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT2 Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
535 a.a.

Protein Preferred Names

Protein Names

T-complex protein 1 subunit beta

T-complex protein 1, beta subunit

Recombinant CCT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72120	CCT2 Protein, Human (His-SUMO)	P78371-1 (A2-C535)	≥95%

Related Diseases

Diseases

Alias

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02179	CCT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CCT2	VGNC	VGNC:60576
Canis familiaris	CCT2	VGNC	VGNC:38922
Rattus norvegicus	CCT2	RGD	RGD:1359143
Macaca mulatta	CCT2	VGNC	VGNC:70745
Bos taurus	CCT2	VGNC	VGNC:26995
Mus musculus	CCT2	MGD	MGI:107186
Others	CCT2	NCBI

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