POLR3G - RNA polymerase III subunit G Gene

Homo sapiens

Also known as C31; RPC7; RPC32

Gene ID: 10622 | Gene type: protein coding

About POLR3G

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:90,473,929-90,514,557 (from NCBI)

This gene has 7 transcripts (splice variants) and 19 orthologues. Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues.

Summary

Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3G Products(5)

mRNA	Protein	Name
NM_001370351.1	NP_001357280.1	DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_001370352.1	NP_001357281.1	DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370353.1	NP_001357282.1	DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370354.1	NP_001357283.1	DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_006467.3	NP_006458.2	DNA-directed RNA polymerase III subunit RPC7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24107381	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20154270	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell population proliferation	IEP IEP: Inferred from expression pattern	24107381	GOA
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	20154270	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase III complex	IDA IDA: Inferred from direct assay	24107381	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20154270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR3G Protein Structure

RNA_pol_3_Rpc31

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase III subunit RPC7

DNA-directed RNA polymerase III 32 kDa polypeptide

POLR3G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLR3G	O15318	POLR3C	Homo sapiens	Q9BUI4	Anti Tag CoIP	35271311
Intra	POLR3G	O15318	POLR3C	Homo sapiens	Q9BUI4	Anti Tag CoIP	20154270
Intra	POLR3G	O15318	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	POLR3G	O15318	POLR3F	Homo sapiens	Q9H1D9	Anti Tag CoIP	35271311
Intra	POLR3G	O15318	POLR3F	Homo sapiens	Q9H1D9	Anti Tag CoIP	20154270

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebellofaciodental Syndrome

Cerebellar-Facial-Dental Syndrome

CFDS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10860	POLR3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POLR3G	RGD	RGD:1593792
Canis familiaris	POLR3G	VGNC	VGNC:44805
Bos taurus	POLR3G	VGNC	VGNC:33151
Macaca mulatta	POLR3G	VGNC	VGNC:84480
Mus musculus	POLR3G	MGD	MGI:1914736

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