POLR3C - RNA polymerase III subunit C Gene

Homo sapiens

Also known as C82; RPC3; RPC62

Gene ID: 10623 | Gene type: protein coding

About POLR3C

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,824,200-145,844,402 (from NCBI)

This gene has 27 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3C Products(2)

mRNA	Protein	Name
NM_001303456.1	NP_001290385.1	DNA-directed RNA polymerase III subunit RPC3 isoform 2
NM_006468.8	NP_006459.3	DNA-directed RNA polymerase III subunit RPC3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11416169	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	21358628	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19609254	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase III complex	IDA IDA: Inferred from direct assay	24107381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR3C Protein Structure

HTH_9

RNA_pol_Rpc82

0
100
200
300
400
500
534 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase III subunit RPC3

DNA-directed III 62 kDa polypeptide

POLR3C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLR3C	Q9BUI4	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	25416956
Intra	POLR3C	Q9BUI4	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	POLR3C	Q9BUI4	PNMA5	Homo sapiens	Q96PV4	Y2H Array	25416956
Intra	POLR3C	Q9BUI4	TNR	Homo sapiens	A1L306	Y2H Prey Pooling	25416956
Intra	POLR3C	Q9BUI4	TNR	Homo sapiens	A1L306	Y2H Array	25416956
Intra	POLR3C	Q9BUI4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	RBBP8NL	Homo sapiens	Q8NC74	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	RBBP8NL	Homo sapiens	Q8NC74	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	UBXN1	Homo sapiens	Q04323-2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	UBXN1	Homo sapiens	Q04323-2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	POLR3G	Homo sapiens	O15318	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	POLR3G	Homo sapiens	O15318	Anti Tag CoIP	35271311
Intra	POLR3C	Q9BUI4	POLR3G	Homo sapiens	O15318	Y2H	21358628
Intra	POLR3C	Q9BUI4	POLR3G	Homo sapiens	O15318	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	25416956
Intra	POLR3C	Q9BUI4	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	POLR3GL	Homo sapiens	Q9BT43	Y2H	21358628
Intra	POLR3C	Q9BUI4	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	SP100	Homo sapiens	P23497-2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	SP100	Homo sapiens	P23497-2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	POLR3F	Homo sapiens	Q9H1D9	Anti Tag CoIP	35271311
Intra	POLR3C	Q9BUI4	POLR3F	Homo sapiens	Q9H1D9	Pull Down	21358628
Intra	POLR3C	Q9BUI4	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	POLR3C	Q9BUI4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	POLR3C	Q9BUI4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	KIAA0408	Homo sapiens	Q6ZU52	MAPPIT	32296183
Intra	POLR3C	Q9BUI4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KLHL2	Homo sapiens	O95198	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	KLHL2	Homo sapiens	O95198	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	POLR3C	Q9BUI4	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	POLR3C	Q9BUI4	ROCK1	Homo sapiens	Q13464	Y2H Prey Pooling	25416956
Intra	POLR3C	Q9BUI4	ROCK1	Homo sapiens	Q13464	Validated Y2H	25416956
Intra	POLR3C	Q9BUI4	COIL	Homo sapiens	P38432	Y2H Prey Pooling	32296183
Intra	POLR3C	Q9BUI4	COIL	Homo sapiens	P38432	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Petroclival Meningioma

Skull Base Meningioma

Meningioma Of The Skull Base

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Chickenpox

Varicella

Varicella Nos

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10857	POLR3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLR3C	VGNC	VGNC:64291
Rattus norvegicus	POLR3C	RGD	RGD:1311545
Canis familiaris	POLR3C	VGNC	VGNC:44802
Mus musculus	POLR3C	MGD	MGI:1921664
Macaca mulatta	POLR3C	VGNC	VGNC:76139
Bos taurus	POLR3C	VGNC	VGNC:33147

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